There is an urgent need to find effective presymptomatic Alzheimer's disease (AD)
treatments that reduce the risk of AD symptoms or prevent them completely. It currently takes …

Molecular genetic analysis is revealing the etiologies of Alzheimer's disease (AD) and
related dementias. Here we review genetic and molecular biological evidence suggesting …

To determine the prevalence of early-onset Alzheimer disease (EOAD) and of autosomal
dominant forms of EOAD (ADEOAD), we performed a population-based study in the city of …

Summary Background Neurofilament light chain (NfL) is a promising biomarker of active
axonal injury and neuronal degeneration. We aimed to characterise cross-sectional and …

Short-term memory binding is a memory function that underpins the temporary retention of
complex objects (eg shapes with colours). In the verbal domain, this function has been found …

The human brain is composed of functional networks that have a modular topology, where
brain regions are organized into communities that form internally dense (segregated) and …

Background Mild cognitive impairment (MCI) and pre-MCI have been proposed as stages
preceding Alzheimer's disease (AD) dementia. We assessed descendants of individuals …

Autosomal dominant Alzheimer's disease (ADAD) is genetically determined, but variability in
age of symptom onset suggests additional factors may influence cognitive trajectories …

Objective The examination of individuals who carry fully penetrant genetic alterations that
result in familial Alzheimer's disease (FAD) provides a unique model for studying the early …

Genetic isolates, as shown empirically by the Finnish, Old Order Amish, Hutterites, Sardinian
and Jewish communities among others, represent a most important and powerful tool in …