▪ Abstract Nerve growth factor (NGF) was discovered 50 years ago as a molecule that
promoted the survival and differentiation of sensory and sympathetic neurons. Its roles in …

The effects of pathogenic organisms on host intestinal epithelial cells are vast. Innumerable
signalling pathways are triggered leading ultimately to drastic changes in physiological …

The mechanisms of cell proliferation and transformation are intrinsically linked to the
process of apoptosis: the default of proliferating cells is to die unless specific survival signals …

Intimal hyperplasia is the process by which the cell population increases within the
innermost layer of the arterial wall, such as occurs physiologically during closure of the …

The initial discovery that ras genes endowed retroviruses with potent carcinogenic
properties and the subsequent determination that mutated ras genes were present in a wide …

I. Introduction IN THE fasted state, glucose homeostasis depends upon the balance between
hepatic glucose production and glucose utilization by the major insulin-dependent tissues …

Embryonic stem cells (ESCs) exist in at least two states that transcriptionally resemble
different stages of embryonic development. Naïve ESCs resemble peri-implantation stages …

The atypical protein kinase C (aPKC)‐interacting protein, p62, has previously been shown to
interact with RIP, linking these kinases to NF‐κB activation by tumor necrosis factor α …

Cell polarity is fundamental to differentiation and function of most cells. Studies in
mammalian epithelial cells have revealed that the establishment and maintenance of cell …

The physiological role of ceramide formation in response to cell stimulation remains
controversial. Here, we emphasize that ceramide is not a priori an apoptotic signalling …