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SLC6 transporters: structure, function, regulation, disease association and therapeutics
The SLC6 family of secondary active transporters are integral membrane solute carrier
proteins characterized by the Na+-dependent translocation of small amino acid or amino …
proteins characterized by the Na+-dependent translocation of small amino acid or amino …
Molecular underpinnings of prefrontal cortex development in rodents provide insights into the etiology of neurodevelopmental disorders
The prefrontal cortex (PFC), seat of the highest-order cognitive functions, constitutes a
conglomerate of highly specialized brain areas and has been implicated to have a role in …
conglomerate of highly specialized brain areas and has been implicated to have a role in …
The molecular genetics of executive function: role of monoamine system genes
Executive control processes, such as sustained attention, response inhibition, and error
monitoring, allow humans to guide behavior in appropriate, flexible, and adaptive ways. The …
monitoring, allow humans to guide behavior in appropriate, flexible, and adaptive ways. The …
Serotonin and decision making processes
JR Homberg - Neuroscience & Biobehavioral Reviews, 2012 - Elsevier
Serotonin (5-HT) is an important player in decision making. Serotonergic antidepressant,
anxiolytic and antipsychotic drugs are extensively used in the treatment of neuropsychiatric …
anxiolytic and antipsychotic drugs are extensively used in the treatment of neuropsychiatric …
A neural model of vulnerability and resilience to stress-related disorders linked to differential susceptibility
JR Homberg, J Jagiellowicz - Molecular Psychiatry, 2022 - nature.com
Expert opinion remains divided concerning the impact of putative risk factors on vulnerability
to depression and other stress-related disorders. A large body of literature has investigated …
to depression and other stress-related disorders. A large body of literature has investigated …
A review of molecular genetic studies of neurocognitive deficits in schizophrenia
Schizophrenia is a complex and debilitating illness with strong genetic loading. In line with
its heterogeneous symptomatology, evidence suggests genetic etiologies for the …
its heterogeneous symptomatology, evidence suggests genetic etiologies for the …
Serotonin transporter gene polymorphism, childhood trauma, and cognition in patients with psychotic disorders
Objective: The functional polymorphism in the promoter region of the SLC6A4/5-HTT
serotonin transporter gene (5-HTTLPR) has been linked to altered stress response. Carriers …
serotonin transporter gene (5-HTTLPR) has been linked to altered stress response. Carriers …
Cognitive dysfunction and glutamate reuptake: effect of EAAT2 polymorphism in schizophrenia
A disturbance of glutamatergic transmission has been suggested to contribute to the
development of schizophrenic pathophysiology, based primarily on the ability of glutamate …
development of schizophrenic pathophysiology, based primarily on the ability of glutamate …
A review of cognitive neuropsychiatry in the taxonomy of eating disorders: state, trait, or genetic?
N Kanakam, J Treasure - Cognitive neuropsychiatry, 2013 - Taylor & Francis
A greater understanding of neuropsychological traits in eating disorders may help to
construct a more biologically based taxonomy. The aim of this paper is to review the current …
construct a more biologically based taxonomy. The aim of this paper is to review the current …
Genetic polymorphisms of 5-HTT and DAT but not COMT differentially affect verbal and visuospatial working memory functioning
D Zilles, J Meyer, T Schneider-Axmann… - European Archives of …, 2012 - Springer
Working memory deficits are found in different psychiatric populations and are most
pronounced in schizophrenia. There is preliminary evidence from pharmacological studies …
pronounced in schizophrenia. There is preliminary evidence from pharmacological studies …