Diffuse intrinsic pontine glioma (DIPG) is a childhood malignancy of the brainstem with a
dismal prognosis. Despite recent advances in its understanding at the molecular level, the …

Immune checkpoint inhibitors (ICIs) have dramatically transformed the treatment landscape
for various malignancies, achieving notable clinical outcomes across a wide range of …

Diffuse midline glioma (DMG), including tumors diagnosed in the brainstem (diffuse intrinsic
pontine glioma-DIPG), is the primary cause of brain tumor-related death in pediatric patients …

The metformin molecule dates back to over a century, but its clinical use started in the '50 s.
Since then, its use in diabetics has grown constantly, with over 150 million users today. The …

Diffuse intrinsic pontine glioma (DIPG) is a devastating brain tumor with a need for novel
therapies. So far, monotherapies have failed to prolong survival for these patients, and …

Simple Summary Subependymal giant cell astrocytoma is a slow-growing brain tumor
affecting children and young adults. Despite the characteristic molecular and clinical …

Objective: Erianin has potential anticancer activities, especially against lung cancer. The
specific mechanisms underlying the anti-cancer effects, including the molecular targets and …

The enhancer of zeste inhibitory protein (EZHIP) is typically expressed during germ cell
development and has been classified as a cancer-testis antigen (CTA) in various cancers. In …

Fewer than 10% of children with diffuse midline glioma (DMG) survive 2 years from
diagnosis. Radiation therapy remains the cornerstone of treatment and there are no …

Purpose We aimed to expand and refine the experimental models for pediatric-type diffuse
high grade gliomas (pHGG) and the methods to follow up disease progression in mouse …