Chronic pulmonary diseases such as asthma, COPD, and Idiopathic pulmonary fibrosis are
significant causes of mortality and morbidity worldwide. Currently, there is no radical …

During organismal development, organs and systems are built following a genetic blueprint
that produces structures capable of performing specific physiological functions. Interestingly …

Tissue morphogenesis occurs in a complex physicochemical microenvironment with limited
experimental accessibility. This often prevents a clear identification of the processes that …

Epithelial branching morphogenesis is an essential process in living organisms, through
which organ-specific epithelial shapes are created. Interactions between epithelial cells and …

Living organisms have the ability to self-shape into complex structures appropriate for their
function. The genetic and molecular mechanisms that enable cells to do this have been …

Organ morphogenesis is multifaceted, multiscale, and fundamentally a robust process.
Despite the complex and dynamic nature of embryonic development, organs are built with …

Abstract Three-dimensional (3D) printing can be beneficial to tissue engineers and the
regenerative medicine community because of its potential to rapidly build elaborate 3D …

The formation of functional epithelial tubules is critical for the development and maintenance
of many organ systems. While the mechanisms of tubule formation by epithelial cells are …

Nature has evolved a variety of mechanisms to build epithelial trees of diverse architectures
within different organs and across species. Epithelial trees are elaborated through branch …

Bottom-up approaches are becoming increasingly popular for studying multicellular self-
organization and development. In contrast to the classic top-down approach, where parts of …