Hair follicles are essential appendages of the mammalian skin, as hair performs vital
functions of protection, thermoregulation and sensation. Hair follicles harbour exceptional …

The mammalian target of rapamycin (mTOR) senses nutrients and growth factors to
coordinate cell growth, metabolism and autophagy. Extensive research has mapped the …

In mammals, endogenous circadian clocks sense and respond to daily feeding and lighting
cues, adjusting internal∼ 24 h rhythms to resonate with, and anticipate, external cycles of …

The current focus in oncology research is the translational control of cancer cells as a major
mechanism of cellular plasticity. Recent evidence has prompted a reevaluation of the role of …

Stem cell activity is subject to non-cell-autonomous regulation from the local
microenvironment, or niche. In adaption to varying physiological conditions and the ever …

Rosacea is a chronic inflammatory skin disorder whose pathogenesis is unclear. Here,
several lines of evidence were provided to demonstrate that mTORC1 signaling is …

Hair plays important roles, ranging from the conservation of body heat to the preservation of
psychological well-being. Hair loss or alopecia affects millions worldwide, but methods that …

Androgenetic alopecia (AGA), also known as male pattern baldness, is associated with
androgen and androgen receptor (AR) signaling; however, the pathogenesis of AGA …

The balance between self-renewal and differentiation ensures long-term maintenance of
stem cell (SC) pools in regenerating epithelial tissues. This balance is challenged during …

The many steps of gene expression, from the transcription of a gene to the production of its
protein product, are well understood. Yet, transcriptional regulation has been the focal point …