Ligand binding and concomitant changes in receptor structure provide the means to target
signal transduction pathways. With appropriate refinement of the ligand's interaction with the …

The search for new peptides to be used as analgesics in place of morphine has been mainly
directed to develop peptide analogues or peptidomimetics having higher biological stability …

Substituted fentanyls are abused and cause rapid fatal overdose. As their pharmacology is
not well characterized, we examined in vitro pharmacology and structure–activity …

Described is a facile helix‐nucleating template based on a tethered aspartic acid at the N‐
terminus [terminal aspartic acid (TD)]. The nucleating effect of the template is subtly …

Identifying neurons that have functional opioid receptors is fundamental for the
understanding of the cellular, synaptic and systems actions of opioids. Current techniques …

The κ-opioid receptor (KOR) is an attractive target for the development of novel drugs. KOR
agonists are potentially safer pain medications, whereas KOR antagonists are promising …

BACKGROUND AND PURPOSE The κ opioid receptor antagonists demonstrate potential for
maintaining abstinence from psychostimulant abuse, but existing non‐peptide κ‐receptor …

The discovery of endogenous opioid peptides 25 years ago opened up a new chapter in
efforts to understand the origins and control of pain, its relationships to other biological …

Melanocortin peptides regulate a variety of physiological processes. Five melanocortin
receptors (MC-R) have been cloned and the MC3R and MC4R are the main brain MC …

The lack of specific receptors (and antagonists) has hampered the research on the neural
mechanism of action of adrenocorticotropic hormone (ACTH)-and melanocyte-stimulating …