The interaction of regulatory proteins with the complex nucleoprotein structures that are
found in mammalian cells involves chromatin reorganization at multiple levels. Mechanisms …

Cells employ elaborate mechanisms to introduce structural and chemical variation into
chromatin. Here, we focus on one such element of variation: methylation of lysine 4 in …

The estrogen receptor (ER), glucocorticoid receptor (GR), and forkhead box protein 1
(FoxA1) are significant factors in breast cancer progression. FoxA1 has been implicated in …

Various chemical modifications on histones and regions of associated DNA play crucial
roles in genome management by binding specific factors that, in turn, serve to alter the …

Androgens, acting through the androgen receptor (AR), are responsible for the development
of the male phenotype during embryogenesis, the achievement of sexual maturation at …

The identification and characterization of mammalian core promoters and transcription start
sites is a prerequisite to understanding how RNA polymerase II transcription is controlled …

Abstract The Neo‐Darwinian concept of natural selection is plausible when one assumes a
straightforward causation of phenotype by genotype. However, such simple 1: 1 map** …

Chromatin is a highly dynamic structure that imparts structural organization to the genome
and regulates the gene expression underneath. The decade long research in deciphering …

Methylation of CpG dinucleotides is generally associated with epigenetic silencing of
transcription and is maintained through cellular division,,. Multiple CpG sequences are rare …

Sp1 and Sp3 are transcription factors expressed in all mammalian cells. These factors are
involved in regulating the transcriptional activity of genes implicated in most cellular …