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Antibodies to combat viral infections: development strategies and progress
Monoclonal antibodies (mAbs) are appealing as potential therapeutics and prophylactics for
viral infections owing to characteristics such as their high specificity and their ability to …
viral infections owing to characteristics such as their high specificity and their ability to …
The germinal centre B cell response to SARS-CoV-2
The germinal centre (GC) response is critical for the generation of affinity-matured plasma
cells and memory B cells capable of mediating long-term protective immunity …
cells and memory B cells capable of mediating long-term protective immunity …
A multivalent nucleoside-modified mRNA vaccine against all known influenza virus subtypes
CP Arevalo, MJ Bolton, V Le Sage, N Ye, C Furey… - Science, 2022 - science.org
Seasonal influenza vaccines offer little protection against pandemic influenza virus strains. It
is difficult to create effective prepandemic vaccines because it is uncertain which influenza …
is difficult to create effective prepandemic vaccines because it is uncertain which influenza …
Immune imprinting and next-generation coronavirus vaccines
Vaccines based on historical virus isolates provide limited protection from continuously
evolving RNA viruses, such as influenza viruses or coronaviruses, which occasionally spill …
evolving RNA viruses, such as influenza viruses or coronaviruses, which occasionally spill …
Antiviral neutralizing antibodies: from in vitro to in vivo activity
DR Burton - Nature Reviews Immunology, 2023 - nature.com
Neutralizing antibodies (nAbs) are being increasingly used as passive antiviral reagents in
prophylactic and therapeutic modalities and to guide viral vaccine design. In vivo, nAbs can …
prophylactic and therapeutic modalities and to guide viral vaccine design. In vivo, nAbs can …
Human seasonal influenza under COVID-19 and the potential consequences of influenza lineage elimination
Annual epidemics of seasonal influenza cause hundreds of thousands of deaths, high levels
of morbidity, and substantial economic loss. Yet, global influenza circulation has been …
of morbidity, and substantial economic loss. Yet, global influenza circulation has been …
Develo** therapeutic approaches for twenty-first-century emerging infectious viral diseases
The twenty-first century has already recorded more than ten major epidemic or pandemic
virus emergence events, including the ongoing and devastating coronavirus disease 2019 …
virus emergence events, including the ongoing and devastating coronavirus disease 2019 …
Influenza vaccine format mediates distinct cellular and antibody responses in human immune organoids
Highly effective vaccines elicit specific, robust, and durable adaptive immune responses. To
advance informed vaccine design, it is critical that we understand the cellular dynamics …
advance informed vaccine design, it is critical that we understand the cellular dynamics …
ACE2-binding exposes the SARS-CoV-2 fusion peptide to broadly neutralizing coronavirus antibodies
The coronavirus spike glycoprotein attaches to host receptors and mediates viral fusion.
Using a broad screening approach, we isolated seven monoclonal antibodies (mAbs) that …
Using a broad screening approach, we isolated seven monoclonal antibodies (mAbs) that …
Messenger RNA-based vaccines: Past, present, and future directions in the context of the COVID-19 pandemic
Abstract mRNA vaccines have received major attention in the fight against COVID-19.
Formulations from companies such as Moderna and BioNTech/Pfizer have allowed us to …
Formulations from companies such as Moderna and BioNTech/Pfizer have allowed us to …