As the home of cellular genetic information, the nucleus has a critical role in determining cell
fate and function in response to various signals and stimuli. In addition to biochemical …

Proteins are the fundamental building blocks for high-performance materials in nature. Such
materials fulfill structural roles, as in the case of silk and collagen, and can generate active …

Many cellular proteins demix spontaneously from solution to form liquid condensates. These
phase-separated structures have wide-ranging roles in health and disease. Elucidating the …

One of the key mechanisms used by cells to control the spatiotemporal organization of their
many components is the formation and dissolution of biomolecular condensates through …

The cellular cytoskeleton self-organizes by specific monomer–monomer interactions
resulting in the polymerization of filaments. While we have long thought about the role of …

One of the key mechanisms employed by cells to control their spatiotemporal organization is
the formation and dissolution of phase-separated condensates. The balance between …

Membraneless organelles formed through condensation of biomolecules in living cells have
become the focus of sustained efforts to elucidate their mechanisms of formation and …

Liquid–liquid phase‐separated biomolecular systems are increasingly recognized as key
components in the intracellular milieu where they provide spatial organization to the …

The presence of Ca2+ ions is known to facilitate the activity of trypsin-like serine proteases
via structural stabilization against thermal denaturation and autolysis. Herein, we report a …

Intrinsically disordered protein (IDP) plays an important role in liquid–liquid phase
separation (LLPS). RNA‐binding protein fused in sarcoma (FUS) is a well‐studied IDP that …