The benefits of antipsychotic medications are sometimes obscured by their adverse effects.
These effects range from relatively minor tolerability issues (eg, mild sedation or dry mouth) …

The American Psychiatric Association Practice Guideline for the Treatment of Patients With
Schizophrenia seeks to reduce these substantial psychosocial and public health …

Abstract Treatment-resistant schizophrenia (TRS) will affect about one in three patients with
schizophrenia. Clozapine is the only treatment approved for TRS, and patients should be …

Background Clozapine is the most effective medication for treatment-refractory
schizophrenia. However, it has a high burden of adverse events, including common adverse …

Background Antipsychotics are a cornerstone of pharmacological treatment of
schizophrenia. Improved understanding of the dose-response relationship of antipsychotics …

Abstract Background and Objective Hypersalivation is a common, clozapine-related adverse
drug reaction with a serious impact on quality of life. Pharmacokinetic correlates of clozapine …

Since the mid-1950s discovery of the first effective antipsychotic medications (APM), we
have only been able to improve the tolerability but not the overall efficacy of currently …

Objectives To investigate the efficacy and tolerability of medications, such as mouthwash
use of 1% atropine sulfate and tropicamide drops, oral amitriptyline and amisulpride used for …

Despite its enduring relevance as the single most effective and important evidence-based
treatment for schizophrenia, underutilization of clozapine remains considerable. To a …

Rationale Clozapine has proven to be superior to other antipsychotic drugs in the treatment
of schizophrenia but is under-prescribed due to its potentially severe side effects. Clozapine …