Novel bioactive natural products from bacteria via bioprospecting, genome mining and metabolic engineering
ON Sekurova, O Schneider… - Microbial biotechnology, 2019 - Wiley Online Library
For over seven decades, bacteria served as a valuable source of bioactive natural products
some of which were eventually developed into drugs to treat infections, cancer and immune …
some of which were eventually developed into drugs to treat infections, cancer and immune …
Carboxylic acid reductase enzymes (CARs)
M Winkler - Current opinion in chemical biology, 2018 - Elsevier
Highlights•Carboxylate reductases (CARs) catalyze the selective one step reduction of an
acid to an aldehyde.•The substrate scope of CARs is broad.•CARs have been implemented …
acid to an aldehyde.•The substrate scope of CARs is broad.•CARs have been implemented …
De novo design and engineering of non-ribosomal peptide synthetases
KAJ Bozhüyük, F Fleischhacker, A Linck, F Wesche… - Nature …, 2018 - nature.com
Peptides derived from non-ribosomal peptide synthetases (NRPSs) represent an important
class of pharmaceutically relevant drugs. Methods to generate novel non-ribosomal …
class of pharmaceutically relevant drugs. Methods to generate novel non-ribosomal …
Modification and de novo design of non-ribosomal peptide synthetases using specific assembly points within condensation domains
KAJ Bozhüyük, A Linck, A Tietze, J Kranz, F Wesche… - Nature …, 2019 - nature.com
Non-ribosomal peptide synthetases (NRPSs) are giant enzyme machines that activate
amino acids in an assembly line fashion. As NRPSs are not restricted to the incorporation of …
amino acids in an assembly line fashion. As NRPSs are not restricted to the incorporation of …
Ribosomally derived lipopeptides containing distinct fatty acyl moieties
Lipopeptides represent a large group of microbial natural products that include important
antibacterial and antifungal drugs and some of the most-powerful known biosurfactants. The …
antibacterial and antifungal drugs and some of the most-powerful known biosurfactants. The …
Structural diversity and biological activities of cyclic depsipeptides from fungi
X Wang, X Gong, P Li, D Lai, L Zhou - Molecules, 2018 - mdpi.com
Cyclic depsipeptides (CDPs) are cyclopeptides in which amide groups are replaced by
corresponding lactone bonds due to the presence of a hydroxylated carboxylic acid in the …
corresponding lactone bonds due to the presence of a hydroxylated carboxylic acid in the …
Beyond peptide bond formation: the versatile role of condensation domains in natural product biosynthesis
S Dekimpe, J Masschelein - Natural product reports, 2021 - pubs.rsc.org
Covering: up to the end of 2020 Nonribosomal peptide synthetases are remarkable
molecular machines that produce a wide range of structurally complex peptide natural …
molecular machines that produce a wide range of structurally complex peptide natural …
Engineering of the Filamentous Fungus Penicillium chrysogenum as Cell Factory for Natural Products
F Guzmán-Chávez, RD Zwahlen… - Frontiers in …, 2018 - frontiersin.org
Penicillium chrysogenum (renamed P. rubens) is the most studied member of a family of
more than 350 Penicillium species that constitute the genus. Since the discovery of penicillin …
more than 350 Penicillium species that constitute the genus. Since the discovery of penicillin …
Bacteria as genetically programmable producers of bioactive natural products
Next to plants, bacteria account for most of the biomass on Earth. They are found
everywhere, although certain species thrive only in specific ecological niches. These …
everywhere, although certain species thrive only in specific ecological niches. These …
Structural advances toward understanding the catalytic activity and conformational dynamics of modular nonribosomal peptide synthetases
Covering: up to fall 2022. Nonribosomal peptide synthetases (NRPSs) are a family of
modular, multidomain enzymes that catalyze the biosynthesis of important peptide natural …
modular, multidomain enzymes that catalyze the biosynthesis of important peptide natural …