Recent advances in lipidomics and metabolomics have unveiled the complexity of fatty acid
metabolism and the fatty acid lipidome in health and disease. A growing body of evidence …

In recent decades, the role of the peroxisome in physiology and disease conditions has
become increasingly important. Together with the mitochondria and other cellular …

The immune response is essential to protect organisms from infection and an altered self. An
organism's overall metabolic status is now recognized as an important and long-overlooked …

Although the pathology of X-linked adrenoleukodystrophy (ALD) is well described, it
represents the end-stage of neurodegeneration. It is still unclear what cell types are initially …

Peroxisomes and their (patho-) physiological importance in heath and disease have
attracted increasing interest during last few decades. Together with mitochondria …

X-linked adrenoleukodystrophy (ALD) is an inherited progressive neurometabolic disease
caused by mutations in the ABCD1 gene and the accumulation of very long-chain fatty acids …

Microglia are crucial for brain homeostasis, and dysfunction of these cells is a key driver in
most neurodegenerative diseases, including peroxisomal leukodystrophies. In X-linked …

Background Adrenoleukodystrophy (ALD) is an X-linked peroxisomal disorder caused by
variants in the ABCD1 gene and can lead to Addison disease, childhood cerebral ALD, or …

X-linked adrenoleukodystrophy (X-ALD) is an inherited disease caused by a mutation in the
ABCD1 gene encoding a peroxisomal transmembrane protein. It is characterized by the …

X-adrenoleukodystrophy (X-ALD) is a peroxisomal metabolic disorder caused by mutations
in the ABCD1 gene encoding the peroxisomal ABC transporter adrenoleukodystrophy …