Nose-to-brain drug delivery: An update on clinical challenges and progress towards approval of anti-Alzheimer drugs

M Agrawal, S Saraf, S Saraf, SG Antimisiaris… - Journal of controlled …, 2018 - Elsevier
Abstract According to the Alzheimer Association Report (2017), Alzheimer's disease (AD) is
the 6th primary cause of death in the USA, which affects nearly 5.5 million people. In the …

Neuroprotective strategies after neonatal hypoxic ischemic encephalopathy

BJ Dixon, C Reis, WM Ho, J Tang… - International journal of …, 2015 - mdpi.com
Neonatal hypoxic ischemic encephalopathy (HIE) is a devastating disease that primarily
causes neuronal and white matter injury and is among the leading cause of death among …

Oxidative stress in the brain: novel cellular targets that govern survival during neurodegenerative disease

ZZ Chong, F Li, K Maiese - Progress in neurobiology, 2005 - Elsevier
Despite our present knowledge of some of the cellular pathways that modulate central
nervous system injury, complete therapeutic prevention or reversal of acute or chronic …

New avenues of exploration for erythropoietin

K Maiese, F Li, ZZ Chong - Jama, 2005 - jamanetwork.com
Discovery that the hormone erythropoietin (EPO) and its receptor play a significant biological
role in tissues outside of the hematopoietic system has fueled significant interest in EPO as a …

Erythropoietin for neuroprotection in neonatal encephalopathy: safety and pharmacokinetics

YW Wu, LA Bauer, RA Ballard, DM Ferriero… - …, 2012 - publications.aap.org
OBJECTIVE: To determine the safety and pharmacokinetics of erythropoietin (Epo) given in
conjunction with hypothermia for hypoxic-ischemic encephalopathy (HIE). We hypothesized …

IFATS collection: the conditioned media of adipose stromal cells protect against hypoxia-ischemia-induced brain damage in neonatal rats

X Wei, Z Du, L Zhao, D Feng, G Wei, Y He, J Tan… - Stem …, 2009 - academic.oup.com
Adipose tissue stroma contains a population of mesenchymal stem cells, which support
repair when administered to damaged tissues, in large part through secreted trophic factors …

Erythropoietin is neuroprotective, improves functional recovery, and reduces neuronal apoptosis and inflammation in a rodent model of experimental closed head …

I Yatsiv, N Grigoriadis, C Simeonidou… - The FASEB …, 2005 - Wiley Online Library
Traumatic brain injury (TBI) is a leading cause of morbidity and mortality in young people in
industrialized countries. Although various anti‐inflammatory and antiapoptotic modalities …

Treatment of neonatal hypoxic-ischemic encephalopathy with erythropoietin alone, and erythropoietin combined with hypothermia: history, current status, and future …

DE Oorschot, RJ Sizemore, AR Amer - International journal of molecular …, 2020 - mdpi.com
Perinatal hypoxic-ischemic encephalopathy (HIE) remains a major cause of morbidity and
mortality. Moderate hypothermia (33.5° C) is currently the sole established standard …

Sex differences in behavioral outcome following neonatal hypoxia ischemia: insights from a clinical meta-analysis and a rodent model of induced hypoxic ischemic …

AL Smith, M Alexander, TS Rosenkrantz… - Experimental …, 2014 - Elsevier
Hypoxia ischemia (HI; reduced oxygen and/or blood flow to the brain) is one of the most
common injuries among preterm infants and term infants with birth complications. Both …

Cannabidiol administration after hypoxia–ischemia to newborn rats reduces long-term brain injury and restores neurobehavioral function

MR Pazos, V Cinquina, A Gómez, R Layunta… - …, 2012 - Elsevier
Cannabidiol (CBD) demonstrated short-term neuroprotective effects in the immature brain
following hypoxia–ischemia (HI). We examined whether CBD neuroprotection is sustained …