Nose-to-brain drug delivery: An update on clinical challenges and progress towards approval of anti-Alzheimer drugs
Abstract According to the Alzheimer Association Report (2017), Alzheimer's disease (AD) is
the 6th primary cause of death in the USA, which affects nearly 5.5 million people. In the …
the 6th primary cause of death in the USA, which affects nearly 5.5 million people. In the …
Neuroprotective strategies after neonatal hypoxic ischemic encephalopathy
BJ Dixon, C Reis, WM Ho, J Tang… - International journal of …, 2015 - mdpi.com
Neonatal hypoxic ischemic encephalopathy (HIE) is a devastating disease that primarily
causes neuronal and white matter injury and is among the leading cause of death among …
causes neuronal and white matter injury and is among the leading cause of death among …
Oxidative stress in the brain: novel cellular targets that govern survival during neurodegenerative disease
ZZ Chong, F Li, K Maiese - Progress in neurobiology, 2005 - Elsevier
Despite our present knowledge of some of the cellular pathways that modulate central
nervous system injury, complete therapeutic prevention or reversal of acute or chronic …
nervous system injury, complete therapeutic prevention or reversal of acute or chronic …
New avenues of exploration for erythropoietin
K Maiese, F Li, ZZ Chong - Jama, 2005 - jamanetwork.com
Discovery that the hormone erythropoietin (EPO) and its receptor play a significant biological
role in tissues outside of the hematopoietic system has fueled significant interest in EPO as a …
role in tissues outside of the hematopoietic system has fueled significant interest in EPO as a …
Erythropoietin for neuroprotection in neonatal encephalopathy: safety and pharmacokinetics
YW Wu, LA Bauer, RA Ballard, DM Ferriero… - …, 2012 - publications.aap.org
OBJECTIVE: To determine the safety and pharmacokinetics of erythropoietin (Epo) given in
conjunction with hypothermia for hypoxic-ischemic encephalopathy (HIE). We hypothesized …
conjunction with hypothermia for hypoxic-ischemic encephalopathy (HIE). We hypothesized …
IFATS collection: the conditioned media of adipose stromal cells protect against hypoxia-ischemia-induced brain damage in neonatal rats
X Wei, Z Du, L Zhao, D Feng, G Wei, Y He, J Tan… - Stem …, 2009 - academic.oup.com
Adipose tissue stroma contains a population of mesenchymal stem cells, which support
repair when administered to damaged tissues, in large part through secreted trophic factors …
repair when administered to damaged tissues, in large part through secreted trophic factors …
Erythropoietin is neuroprotective, improves functional recovery, and reduces neuronal apoptosis and inflammation in a rodent model of experimental closed head …
I Yatsiv, N Grigoriadis, C Simeonidou… - The FASEB …, 2005 - Wiley Online Library
Traumatic brain injury (TBI) is a leading cause of morbidity and mortality in young people in
industrialized countries. Although various anti‐inflammatory and antiapoptotic modalities …
industrialized countries. Although various anti‐inflammatory and antiapoptotic modalities …
Treatment of neonatal hypoxic-ischemic encephalopathy with erythropoietin alone, and erythropoietin combined with hypothermia: history, current status, and future …
DE Oorschot, RJ Sizemore, AR Amer - International journal of molecular …, 2020 - mdpi.com
Perinatal hypoxic-ischemic encephalopathy (HIE) remains a major cause of morbidity and
mortality. Moderate hypothermia (33.5° C) is currently the sole established standard …
mortality. Moderate hypothermia (33.5° C) is currently the sole established standard …
Sex differences in behavioral outcome following neonatal hypoxia ischemia: insights from a clinical meta-analysis and a rodent model of induced hypoxic ischemic …
AL Smith, M Alexander, TS Rosenkrantz… - Experimental …, 2014 - Elsevier
Hypoxia ischemia (HI; reduced oxygen and/or blood flow to the brain) is one of the most
common injuries among preterm infants and term infants with birth complications. Both …
common injuries among preterm infants and term infants with birth complications. Both …
Cannabidiol administration after hypoxia–ischemia to newborn rats reduces long-term brain injury and restores neurobehavioral function
Cannabidiol (CBD) demonstrated short-term neuroprotective effects in the immature brain
following hypoxia–ischemia (HI). We examined whether CBD neuroprotection is sustained …
following hypoxia–ischemia (HI). We examined whether CBD neuroprotection is sustained …