Apoptosis is a form of regulated cell death (RCD) that involves proteases of the caspase
family. Pharmacological and genetic strategies that experimentally inhibit or delay apoptosis …

Most metastatic cancers remain incurable due to the emergence of apoptosis-resistant
clones, fuelled by intratumour heterogeneity and tumour evolution. To improve treatment …

Cell suicide pathways, termed regulated cell death (RCD), play a critical role in organismal
development, homeostasis, and pathogenesis. Here, we provide an overview of key RCD …

Pyroptosis and necroptosis represent two pathways of genetically encoded necrotic cell
death. Although these cell death programmes can protect the host against microbial …

Ferroptosis is a nonapoptotic, iron-dependent form of cell death that can be activated in
cancer cells by natural stimuli and synthetic agents. Three essential hallmarks define …

Various forms of cell death have been identified over the last decades with each relying on a
different subset of proteins for the activation and execution of their respective pathway (s). In …

Caspases are an evolutionary conserved family of cysteine-dependent proteases that are
involved in many vital cellular processes including apoptosis, proliferation, differentiation …

Background & Aims Non-alcoholic steatohepatitis (NASH) is characterized by hepatocyte
steatosis, ballooning, and lobular inflammation which may lead to fibrosis. Lipotoxicity …

Cell death plays an important role during pathogen infections. Here, we report that interferon-
γ (IFNγ) sensitizes macrophages to Toll-like receptor (TLR)-induced death that requires …

Regulated cell death is intrinsically associated with inflammatory liver disease and is pivotal
in governing outcomes of metabolic liver disease. Different types of cell death may coexist …