The current landscape of immune checkpoint blockade in hepatocellular carcinoma: a review

M Pinter, RK Jain, DG Duda - JAMA oncology, 2021‏ - jamanetwork.com
Importance For more than a decade, sorafenib has been the only systemic treatment option
for patients with advanced hepatocellular carcinoma (HCC). However, rapid progress over …

Targeting the renin-angiotensin system to improve cancer treatment: Implications for immunotherapy

M Pinter, RK Jain - Science translational medicine, 2017‏ - science.org
Renin-angiotensin system (RAS) inhibitors (RASi)—widely prescribed for the treatment of
cardiovascular diseases—have considerable potential in oncology. The RAS plays a crucial …

Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels

VP Chauhan, JD Martin, H Liu, DA Lacorre… - Nature …, 2013‏ - nature.com
Cancer and stromal cells actively exert physical forces (solid stress) to compress tumour
blood vessels, thus reducing vascular perfusion. Tumour interstitial matrix also contributes to …

Macrophages: an inflammatory link between angiogenesis and lymphangiogenesis

BA Corliss, MS Azimi, JM Munson, SM Peirce… - …, 2016‏ - Wiley Online Library
Angiogenesis and lymphangiogenesis often occur in response to tissue injury or in the
presence of pathology (eg, cancer), and it is these types of environments in which …

Cardio-oncology-strategies for management of cancer-therapy related cardiovascular disease

M Totzeck, M Schuler, M Stuschke, G Heusch… - International Journal of …, 2019‏ - Elsevier
Current therapy of advanced cancers is based on several modalities including radiotherapy,
cytotoxic chemotherapy, molecularly targeted inhibitors and antibodies targeting immune …

The renin–angiotensin system and cancer: old dog, new tricks

AJ George, WG Thomas, RD Hannan - Nature Reviews Cancer, 2010‏ - nature.com
For cancers to develop, sustain and spread, the appropriation of key homeostatic
physiological systems that influence cell growth, migration and death, as well as …

Redox signaling in angiogenesis: role of NADPH oxidase

M Ushio-Fukai - Cardiovascular research, 2006‏ - academic.oup.com
Angiogenesis, a process of new blood vessel formation, is a key process involved in normal
development and wound repair as well as in the various pathophysiologies such as …

Reactive oxygen species as mediators of angiogenesis signaling. Role of NAD(P)H oxidase

M Ushio-Fukai, RW Alexander - Molecular and cellular biochemistry, 2004‏ - Springer
Angiogenesis, a process of new blood vessel growth, contributes to various
pathophysiologies such as cancer, diabetic retinopathy and atherosclerosis. Accumulating …

Histological changes of kidney in diabetic nephropathy

M Pourghasem, H Shafi… - Caspian journal of …, 2015‏ - pmc.ncbi.nlm.nih.gov
Diabetes mellitus is the most common cause of chronic renal disorders and end-stage
kidney disease in developed countries. It is the major cause of dialysis and transplantation …

[PDF][PDF] Angiotensin‐II type 1 receptor interaction is a major regulator for liver fibrosis development in rats

H Yoshiji, S Kuriyama, J Yoshii, Y Ikenaka… - …, 2001‏ - Wiley Online Library
The renin‐angiotensin system (RAS) is frequently activated in patients with chronic liver
diseases. Angiotensin‐II (AT‐II) has been suggested to play an important role in liver …