Purines and their derivatives, most notably adenosine and ATP, are the key molecules
controlling intracellular energy homoeostasis and nucleotide synthesis. Besides, these …

Oncolytic viruses can be usefully integrated into tumour immunotherapies, as they target
multiple steps within the cancer–immunity cycle. Oncolytic viruses directly lyse tumour cells …

T cells play a critical role in cancer control, but a range of potent immunosuppressive
mechanisms can be upregulated in the tumor microenvironment (TME) to abrogate their …

Significance: The nicotinamide adenine dinucleotide (NAD+)/reduced NAD+ (NADH) and
NADP+/reduced NADP+ (NADPH) redox couples are essential for maintaining cellular …

Despite lack of tumor control in many models, spontaneous T cell priming occurs frequently
in response to a growing tumor. However, the innate immune mechanisms that promote …

Significance: Nicotinamide adenine dinucleotide (NAD+) is an essential pyridine nucleotide
that serves as an essential cofactor and substrate for a number of critical cellular processes …

Abstract Immune-checkpoint inhibitors (ICI), although revolutionary in improving long-term
survival outcomes, are mostly effective in patients with immune-responsive tumors. Most …

Posttranslational modifications (PTMs) regulate protein functions and interactions. ADP-
ribosylation is a PTM, in which ADP-ribosyltransferases use nicotinamide adenine …

Nicotinamide, the amide form of vitamin B3 (niacin), has long been associated with neuronal
development, survival, and function in the central nervous system (CNS), being implicated in …

Purpose of Review NAD+ is a vital molecule that takes part as a redox cofactor in several
metabolic reactions besides being used as a substrate in important cellular signaling in …