Replication and transcription of Human mitochondrial DNA
M Falkenberg, NG Larsson… - Annual Review of …, 2024 - annualreviews.org
Mammalian mitochondrial DNA (mtDNA) is replicated and transcribed by phage-like DNA
and RNA polymerases, and our understanding of these processes has progressed …
and RNA polymerases, and our understanding of these processes has progressed …
Organization and expression of the mammalian mitochondrial genome
O Rackham, A Filipovska - Nature Reviews Genetics, 2022 - nature.com
The mitochondrial genome encodes core subunits of the respiratory chain that drives
oxidative phosphorylation and is, therefore, essential for energy conversion. Advances in …
oxidative phosphorylation and is, therefore, essential for energy conversion. Advances in …
Mechanisms and regulation of human mitochondrial transcription
BG Tan, CM Gustafsson, M Falkenberg - Nature Reviews Molecular Cell …, 2024 - nature.com
The expression of mitochondrial genes is regulated in response to the metabolic needs of
different cell types, but the basic mechanisms underlying this process are still poorly …
different cell types, but the basic mechanisms underlying this process are still poorly …
The dynamics of mitochondrial DNA heteroplasmy: implications for human health and disease
Common genetic variants of mitochondrial DNA (mtDNA) increase the risk of develo**
several of the major health issues facing the western world, including neurodegenerative …
several of the major health issues facing the western world, including neurodegenerative …
Mitochondrial transcription and translation: overview
AR D'Souza, M Minczuk - Essays in biochemistry, 2018 - portlandpress.com
Mitochondria are the major source of ATP in the cell. Five multi-subunit complexes in the
inner membrane of the organelle are involved in the oxidative phosphorylation required for …
inner membrane of the organelle are involved in the oxidative phosphorylation required for …
Maintenance and expression of mammalian mitochondrial DNA
CM Gustafsson, M Falkenberg… - Annual review of …, 2016 - annualreviews.org
Mammalian mitochondrial DNA (mtDNA) encodes 13 proteins that are essential for the
function of the oxidative phosphorylation system, which is composed of four respiratory …
function of the oxidative phosphorylation system, which is composed of four respiratory …
[HTML][HTML] Mitochondrial OXPHOS biogenesis: co-regulation of protein synthesis, import, and assembly pathways
The assembly of mitochondrial oxidative phosphorylation (OXPHOS) complexes is an
intricate process, which—given their dual-genetic control—requires tight co-regulation of two …
intricate process, which—given their dual-genetic control—requires tight co-regulation of two …
Mitochondrial DNA transcription and its regulation: an evolutionary perspective
The bacterial heritage of mitochondria, as well as its independent genome [mitochondrial
DNA (mtDNA)] and polycistronic transcripts, led to the view that mitochondrial transcriptional …
DNA (mtDNA)] and polycistronic transcripts, led to the view that mitochondrial transcriptional …
NSUN4 is a dual function mitochondrial protein required for both methylation of 12S rRNA and coordination of mitoribosomal assembly
MD Metodiev, H Spåhr, P Loguercio Polosa… - PLoS …, 2014 - journals.plos.org
Biogenesis of mammalian mitochondrial ribosomes requires a concerted maturation of both
the small (SSU) and large subunit (LSU). We demonstrate here that the m5C …
the small (SSU) and large subunit (LSU). We demonstrate here that the m5C …
Respiratory complex and tissue lineage drive recurrent mutations in tumour mtDNA
Mitochondrial DNA (mtDNA) encodes protein subunits and translational machinery required
for oxidative phosphorylation (OXPHOS). Using repurposed whole-exome sequencing data …
for oxidative phosphorylation (OXPHOS). Using repurposed whole-exome sequencing data …