Innovation trends in industrial biotechnology

J Nielsen, CB Tillegreen, D Petranovic - Trends in biotechnology, 2022 - cell.com
Microbial fermentations are used for the sustainable production of a range of products. Due
to increasing trends in the food sector toward plant-based foods and meat and dairy product …

A comprehensive review of spermidine: Safety, health effects, absorption and metabolism, food materials evaluation, physical and chemical processing, and …

D Zou, Z Zhao, L Li, Y Min, D Zhang, A Ji… - … Reviews in Food …, 2022 - Wiley Online Library
Spermidine, a natural autophagy inducer, has a variety of health effects, such as antitumor,
antiaging, anti‐inflammation, cardiovascular protection, and neuromodulation. It has been a …

De novo biosynthesis of rubusoside and rebaudiosides in engineered yeasts

Y Xu, X Wang, C Zhang, X Zhou, X Xu, L Han… - Nature …, 2022 - nature.com
High-sugar diet causes health problems, many of which can be addressed with the use of
sugar substitutes. Rubusoside and rebaudiosides are interesting molecules, considered the …

Genome-scale modeling of yeast metabolism: retrospectives and perspectives

Y Chen, F Li, J Nielsen - FEMS Yeast Research, 2022 - academic.oup.com
Yeasts have been widely used for production of bread, beer and wine, as well as for
production of bioethanol, but they have also been designed as cell factories to produce …

Polyamine-containing natural products: structure, bioactivity, and biosynthesis

Q Long, W Zhou, H Zhou, Y Tang, W Chen… - Natural Product …, 2024 - pubs.rsc.org
Covering: 2005 to August, 2023 Polyamine-containing natural products (NPs) have been
isolated from a wide range of terrestrial and marine organisms and most of them exhibit …

A pathway independent multi-modular ordered control system based on thermosensors and CRISPRi improves bioproduction in Bacillus subtilis

W Yu, K **, Y Wu, Q Zhang, Y Liu, J Li… - Nucleic Acids …, 2022 - academic.oup.com
Dynamic regulation is an effective strategy for control of gene expression in microbial cell
factories. In some pathway contexts, several metabolic modules must be controlled in a time …

Advances in genome-scale metabolic models of industrially important fungi

Y Han, AT Rangel, KR Pomraning… - Current Opinion in …, 2023 - Elsevier
Highlights•Genome-scale models are available for many industrially important
fungi.•Enzyme-constrained genome-scale models improve simulation …

Efficient production of protocatechuic acid using systems engineering of Escherichia coli

M Wang, H Wang, C Gao, W Wei, J Liu, X Chen… - Metabolic …, 2024 - Elsevier
Abstract Protocatechuic acid (3, 4-dihydroxybenzoic acid, PCA) is widely used in the
pharmaceuticals, health food, and cosmetics industries owing to its diverse biological …

[HTML][HTML] Supplying plant natural products by yeast cell factories

D Romero-Suarez, JD Keasling, MK Jensen - Current Opinion in Green …, 2022 - Elsevier
Plant natural products have been used for centuries to treat human illnesses, as recreational
substances, and as flavoring and coloring agents in our food. Nowadays, commercial-scale …

Metabolic Engineering of Saccharomyces cerevisiae for Vitamin B5 Production

J Guo, X Sun, Y Yuan, Q Chen, Z Ou… - Journal of Agricultural …, 2023 - ACS Publications
Vitamin B5, also called d-pantothenic acid, is an essential vitamin in the human body and is
widely used in pharmaceuticals, nutritional supplements, food, and cosmetics. However, few …