The clinical profile and pathophysiology of atrial fibrillation: relationships among clinical features, epidemiology, and mechanisms

J Andrade, P Khairy, D Dobrev, S Nattel - Circulation research, 2014 - Am Heart Assoc
Atrial fibrillation (AF) is the most common arrhythmia (estimated lifetime risk, 22%–26%). The
aim of this article is to review the clinical epidemiological features of AF and to relate them to …

Molecular basis of atrial fibrillation pathophysiology and therapy: a translational perspective

S Nattel, J Heijman, L Zhou, D Dobrev - Circulation research, 2020 - Am Heart Assoc
Atrial fibrillation (AF) is a highly prevalent arrhythmia, with substantial associated morbidity
and mortality. There have been significant management advances over the past 2 decades …

Atrial fibrillation pathophysiology: implications for management

Y Iwasaki, K Nishida, T Kato, S Nattel - Circulation, 2011 - Am Heart Assoc
Atrial fibrillation (AF), the most common sustained cardiac arrhythmia, is an important
contributor to population morbidity and mortality. An arrhythmia that is particularly common …

Atrial remodeling and atrial fibrillation: recent advances and translational perspectives

S Nattel, M Harada - Journal of the American College of Cardiology, 2014 - jacc.org
Atrial fibrillation (AF) is the most common sustained arrhythmia in clinical practice. AF and its
complications are responsible for important population morbidity and mortality. Presently …

Cellular and molecular electrophysiology of atrial fibrillation initiation, maintenance, and progression

J Heijman, N Voigt, S Nattel, D Dobrev - Circulation research, 2014 - Am Heart Assoc
Atrial fibrillation (AF) is the most common clinically relevant arrhythmia and is associated
with increased morbidity and mortality. The incidence of AF is expected to continue to rise …

Molecular and cellular mechanisms of atrial fibrosis in atrial fibrillation

S Nattel - JACC: Clinical Electrophysiology, 2017 - jacc.org
Atrial fibrillation (AF) is the most common arrhythmia in clinical practice. Atrial fibrosis has
emerged as an important pathophysiological contributor and has been linked to AF …

Computationally guided personalized targeted ablation of persistent atrial fibrillation

PM Boyle, T Zghaib, S Zahid, RL Ali, D Deng… - Nature biomedical …, 2019 - nature.com
Atrial fibrillation (AF)—the most common arrhythmia—significantly increases the risk of
stroke and heart failure. Although catheter ablation can restore normal heart rhythms …

Recent advances in the molecular pathophysiology of atrial fibrillation

R Wakili, N Voigt, S Kääb, D Dobrev… - The Journal of clinical …, 2011 - Am Soc Clin Investig
Atrial fibrillation (AF) is an extremely common cardiac rhythm disorder that causes
substantial morbidity and contributes to mortality. The mechanisms underlying AF are …

[HTML][HTML] Role of gut microbiota in cardiovascular diseases

M Novakovic, A Rout, T Kingsley, R Kirchoff… - World journal of …, 2020 - ncbi.nlm.nih.gov
The human gut is colonized by a community of microbiota, primarily bacteria, that exist in a
symbiotic relationship with the host. Intestinal microbiota-host interactions play a critical role …

Atrial fibrillation promotion by endurance exercise: demonstration and mechanistic exploration in an animal model

E Guasch, B Benito, X Qi, C Cifelli, P Naud… - Journal of the American …, 2013 - jacc.org
Objectives: The goal of this study was to assess mechanisms underlying atrial fibrillation
(AF) promotion by exercise training in an animal model. Background: High-level exercise …