Large animal models in regenerative medicine and tissue engineering: to do or not to do

I Ribitsch, PM Baptista, A Lange-Consiglio… - … in Bioengineering and …, 2020 - frontiersin.org
Rapid developments in Regenerative Medicine and Tissue Engineering has witnessed an
increasing drive toward clinical translation of breakthrough technologies. However, the …

Harnessing genomic information for livestock improvement

M Georges, C Charlier, B Hayes - Nature Reviews Genetics, 2019 - nature.com
The world demand for animal-based food products is anticipated to increase by 70% by
2050. Meeting this demand in a way that has a minimal impact on the environment will …

Ensembl 2023

FJ Martin, MR Amode, A Aneja… - Nucleic acids …, 2023 - academic.oup.com
Abstract Ensembl (https://www. ensembl. org) has produced high-quality genomic resources
for vertebrates and model organisms for more than twenty years. During that time, our …

Large-scale ruminant genome sequencing provides insights into their evolution and distinct traits

L Chen, Q Qiu, YU Jiang, K Wang, Z Lin, Z Li, F Bibi… - Science, 2019 - science.org
INTRODUCTION The ruminants are one of the most successful mammalian lineages,
exhibiting extensive morphological and ecological diversity and containing several key …

Whole-genome resequencing of wild and domestic sheep identifies genes associated with morphological and agronomic traits

X Li, JI Yang, M Shen, XL **e, GJ Liu, YX Xu… - Nature …, 2020 - nature.com
Understanding the genetic changes underlying phenotypic variation in sheep (Ovis aries)
may facilitate our efforts towards further improvement. Here, we report the deep …

The Ensembl gene annotation system

BL Aken, S Ayling, D Barrell, L Clarke, V Curwen… - Database, 2016 - academic.oup.com
The Ensembl gene annotation system has been used to annotate over 70 different
vertebrate species across a wide range of genome projects. Furthermore, it generates the …

Building a livestock genetic and genomic information knowledgebase through integrative developments of Animal QTLdb and CorrDB

ZL Hu, CA Park, JM Reecy - Nucleic acids research, 2019 - academic.oup.com
Successful development of biological databases requires accommodation of the burgeoning
amounts of data from high-throughput genomics pipelines. As the volume of curated data in …

[HTML][HTML] D-SCRIPT translates genome to phenome with sequence-based, structure-aware, genome-scale predictions of protein-protein interactions

S Sledzieski, R Singh, L Cowen, B Berger - Cell Systems, 2021 - cell.com
We combine advances in neural language modeling and structurally motivated design to
develop D-SCRIPT, an interpretable and generalizable deep-learning model, which predicts …

Landscape of adenosine-to-inosine RNA recoding across human tissues

O Gabay, Y Shoshan, E Kopel, U Ben-Zvi… - Nature …, 2022 - nature.com
RNA editing by adenosine deaminases changes the information encoded in the mRNA from
its genomic blueprint. Editing of protein-coding sequences can introduce novel, functionally …