The exploration of privileged structures in drug discovery is a rapidly emerging theme in
medicinal chemistry. These structures represent a class of molecules capable of binding to …

Natural products have long been an important source for discovery of new drugs to treat
human diseases. Piperlongumine (PL) is an amide alkaloid isolated from Piper longum …

Herein we report a novel strategy for the design and construction of natural and natural
product-like libraries based on the principle of privileged structures, a term originally …

Six flavonoids [xanthohumol (XN), 2′, 4′, 6′, 4-tetrahydroxy-3′-prenylchalcone (TP);
2′, 4′, 6′, 4-tetrahydroxy-3′-geranylchalcone (TG); dehydrocycloxanthohumol (DX); …

Chalcones are absorbed in the daily diet and appear to be promising cancer
chemopreventive agents. Chalcones represent an important group of the polyphenolic …

Fourteen novel C-prenylated and O-allylated 1, 3-diarylpropenones (chalcones) were
synthesized by Claisen–Schmidt condensation reaction of C-prenylated/O-allylated …

Licorice is an important Chinese materia medica frequently used in clinical practice, which
contains more than 20 triterpenoids and 300 flavonoids. Chalcone, one of the major classes …

Background The present study was designed to investigate the antibacterial activities of the
methanol extracts of four Cameroonian edible plants, locally used to treat microbial …

Purpose: Among flavonoids, chalcones have been identified as interesting compounds
having chemopreventive and antitumor properties. We studied a panel of newly developed …

The female inflorescences of the hop plant (Humulus lupulus L.) are essential during
brewing to add taste and flavor to beer and to stabilize beer foam. Xanthohumol, the main …