In recent years, the T1799A B-type Raf kinase (BRAF) mutation in thyroid cancer has
received enthusiastic investigation, and significant progress has been made toward …

Tumor cells have an increased demand for nutrients; this demand is met by increased
availability of nutrients through vasculogenesis and by enhanced cellular entry of nutrients …

The role of aberrant tumor suppressor gene methylation in the aggressiveness of papillary
thyroid cancer (PTC) has not been documented. By showing promoter methylation‐induced …

The identification of SLC5A8 as a tumor suppressor gene in colorectal cancer marks, for the
first time, the association of a plasma membrane transporter with tumor suppressive …

Glioblastoma multiforme (GBM) is an aggressive and lethal cancer, accounting for the
majority of primary brain tumors in adults. GBMs are characterized by genetic alterations …

Aberrant gene methylation plays an important role in human tumorigenesis, including
thyroid tumorigenesis. Many tumor suppressor genes are aberrantly methylated in thyroid …

The Warburg effect refers to the phenomenon whereby cancer cells avidly take up glucose
and produce lactic acid under aerobic conditions. Although the molecular mechanisms …

Human colon cancer cells and primary colon cancer silence the gene coding for LDH
(lactate dehydrogenase)-B and up-regulate the gene coding for LDH-A, resulting in effective …

Membrane transporters enable efficient cellular metabolism, aid in nutrient sensing, and
have been associated with various diseases, such as obesity and cancer. Genome-scale …

Rarely has a chemical elicited as much controversy as dichloroacetate (DCA). DCA was
initially considered a dangerous toxic industrial waste product, then a potential treatment for …