MS‐based glycomics and glycoproteomics methods enabling isomeric characterization
Glycosylation is one of the most significant and abundant posttranslational modifications in
mammalian cells. It mediates a wide range of biofunctions, including cell adhesion, cell …
mammalian cells. It mediates a wide range of biofunctions, including cell adhesion, cell …
Applications and continued evolution of glycan imaging mass spectrometry
Glycosylation is an important posttranslational modifier of proteins and lipid conjugates
critical for the stability and function of these macromolecules. Particularly important are N …
critical for the stability and function of these macromolecules. Particularly important are N …
FUT8 promotes breast cancer cell invasiveness by remodeling TGF-β receptor core fucosylation
CF Tu, MY Wu, YC Lin, R Kannagi, RB Yang - Breast Cancer Research, 2017 - Springer
Background Core fucosylation (addition of fucose in α-1, 6-linkage to core N-
acetylglucosamine of N-glycans) catalyzed by fucosyltransferase 8 (FUT8) is critical for …
acetylglucosamine of N-glycans) catalyzed by fucosyltransferase 8 (FUT8) is critical for …
Omics, big data and machine learning as tools to propel understanding of biological mechanisms and to discover novel diagnostics and therapeutics
Conclusions Omics are high throughput procedures able to provide important information at
different levels (gene, mRNA, protein, metabolite level, etc.) in complicated biological …
different levels (gene, mRNA, protein, metabolite level, etc.) in complicated biological …
[HTML][HTML] N-glycosylation stabilizes MerTK and promotes hepatocellular carcinoma tumor growth
Y Liu, L Lan, Y Li, J Lu, L He, Y Deng, M Fei, JW Lu… - Redox biology, 2022 - Elsevier
Despite the evidences of elevated expression of Mer tyrosine kinase (MerTK) in multiple
human cancers, mechanisms underlying the oncogenic roles of MerTK in hepatocellular …
human cancers, mechanisms underlying the oncogenic roles of MerTK in hepatocellular …
Brilliant glycans and glycosylation: Seq and ye shall find
Proteoglycosylation is the addition of monosaccharides or glycans to the protein peptide
chain. This is a common post-translational modification of proteins with a variety of biological …
chain. This is a common post-translational modification of proteins with a variety of biological …
Alpha-1-antichymotrypsin as a novel biomarker for diagnosis, prognosis, and therapy prediction in human diseases
Y **, W Wang, Q Wang, Y Zhang, KR Zahid… - Cancer cell …, 2022 - Springer
Abstract The glycoprotein alpha-1-antichymotrypsin (AACT), a serine protease inhibitor, is
mainly synthesized in the liver and then secreted into the blood and is involved in the acute …
mainly synthesized in the liver and then secreted into the blood and is involved in the acute …
Fucosylation in cancer biology and its clinical applications
M Shan, D Yang, H Dou, L Zhang - Progress in molecular biology and …, 2019 - Elsevier
Fucosylation is the process of transferring fucose from GDP-fucose to their substrates, which
includes certain proteins, N-and O-linked glycans in glycoprotein or glycolipids, by …
includes certain proteins, N-and O-linked glycans in glycoprotein or glycolipids, by …
Advances in mass spectrometry‐based glycomics
The diversification of the chemical properties and biological functions of proteins is attained
through posttranslational modifications, such as glycosylation. Glycans, which are covalently …
through posttranslational modifications, such as glycosylation. Glycans, which are covalently …
Traditional Chinese medicine: An important source for discovering candidate agents against hepatic fibrosis
WQ Li, WH Liu, D Qian, J Liu, SQ Zhou… - Frontiers in …, 2022 - frontiersin.org
Hepatic fibrosis (HF) refers to the pathophysiological process of connective tissue dysplasia
in the liver caused by various pathogenic factors. Nowadays, HF is becoming a severe threat …
in the liver caused by various pathogenic factors. Nowadays, HF is becoming a severe threat …