The decline of oxygen tension in the tissues below the physiological demand leads to the
hypoxic adaptive response. This physiological consequence enables cells to recover from …

Hypoxia-inducible factors (HIFs) are transcription factors that reprogram the transcriptome
for cells to survive hypoxic insults and oxidative stress. They are important during embryonic …

The cellular adaptive response to hypoxia relies on the expression of hypoxia-inducible
factors (HIFs), HIF-1 and HIF-2. HIFs regulate global gene expression changes during …

Erythropoiesis is a complex process driving the production of red blood cells. During
homeostasis, adult erythropoiesis takes place in the bone marrow and is tightly controlled by …

Monge's disease (chronic mountain sickness (CMS)) is a maladaptive condition caused by
chronic (years) exposure to high-altitude hypoxia. One of the defining features of CMS is …

MicroRNA expression profiling and bioinformatics analysis of... : Medicine MicroRNA
expression profiling and bioinformatics analysis of dysregulated microRNAs in obstructive sleep …

To adapt to a low-oxygen environment, Tibetan pigs have developed a series of unique
characteristics and can transport oxygen more effectively; however, the regulation of the …

GATA-1 is a key regulator of hematopoiesis. A balanced ratio of its two isoforms, GATA-1FL
and GATA-1S, contributes to normal hematopoiesis, whereas aberrant expression of GATA …

Thrombocytopenia is a thrombopoietin (TPO)-related disorder with very limited treatment
options, and can be life-threatening. There are major problems with typical thrombopoietic …

Oxygen sensing is of paramount importance for maintaining cellular and systemic
homeostasis. In response to diminished oxygen levels, the hypoxia-inducible factors (HIFs) …