Beyond mass spectrometry, the next step in proteomics

W Timp, G Timp - Science Advances, 2020 - science.org
Proteins can be the root cause of a disease, and they can be used to cure it. The need to
identify these critical actors was recognized early (1951) by Sanger; the first biopolymer …

Engineering biological nanopore approaches toward protein sequencing

X Wei, T Penkauskas, JE Reiner, C Kennard… - ACS …, 2023 - ACS Publications
Biotechnological innovations have vastly improved the capacity to perform large-scale
protein studies, while the methods we have for identifying and quantifying individual proteins …

Recent progress in solid‐state nanopores

K Lee, KB Park, HJ Kim, JS Yu, H Chae… - Advanced …, 2018 - Wiley Online Library
The solid‐state nanopore has attracted much attention as a next‐generation DNA
sequencing tool or a single‐molecule biosensor platform with its high sensitivity of …

Comparing current noise in biological and solid-state nanopores

A Fragasso, S Schmid, C Dekker - ACS nano, 2020 - ACS Publications
Nanopores bear great potential as single-molecule tools for bioanalytical sensing and
sequencing, due to their exceptional sensing capabilities, high-throughput, and low cost …

Ultrafast polymer dynamics through a nanopore

CY Lin, R Fotis, Z **a, K Kavetsky, YC Chou… - Nano Letters, 2022 - ACS Publications
Ultrathin nanopore sensors allow single-molecule and polymer measurements at sub-
microsecond time resolution enabled by high current signals (∼ 10–30 nA). We …

Coupled nanopores for single-molecule detection

YC Chou, CY Lin, A Castan, J Chen, R Keneipp… - Nature …, 2024 - nature.com
Rapid sensing of molecules is increasingly important in many studies and applications, such
as DNA sequencing and protein identification. Here, beyond atomically thin 2D nanopores …

Super‐Resolution Detection of DNA Nanostructures Using a Nanopore

K Chen, A Choudhary, SE Sandler, C Maffeo… - Advanced …, 2023 - Wiley Online Library
High‐resolution analysis of biomolecules has brought unprecedented insights into
fundamental biological processes and dramatically advanced biosensing. Notwithstanding …

Fabrication and practical applications of molybdenum disulfide nanopores

M Graf, M Lihter, M Thakur, V Georgiou, J Topolancik… - Nature protocols, 2019 - nature.com
Among the different developed solid-state nanopores, nanopores constructed in a
monolayer of molybdenum disulfide (MoS2) stand out as powerful devices for single …

Solid-state and polymer nanopores for protein sensing: A review

N Meyer, I Abrao-Nemeir, JM Janot, J Torrent… - Advances in colloid and …, 2021 - Elsevier
In two decades, the solid state and polymer nanopores became attractive method for the
protein sensing with high specificity and sensitivity. They also allow the characterization of …

Measurement of DNA translocation dynamics in a solid-state nanopore at 100 ns temporal resolution

S Shekar, DJ Niedzwiecki, CC Chien, P Ong… - Nano …, 2016 - ACS Publications
Despite the potential for nanopores to be a platform for high-bandwidth study of single-
molecule systems, ionic current measurements through nanopores have been limited in …