Major recent advances and previous data have led to a plausible model of how key proteins
mediate neurotransmitter release. In this model, the soluble N-ethylmaleimide-sensitive …

During an action potential, Ca 2+ entering a presynaptic terminal triggers synaptic vesicle
exocytosis and neurotransmitter release in less than a millisecond. How does Ca 2+ …

Persistent changes in tree mortality rates can alter forest structure, composition, and
ecosystem services such as carbon sequestration. Our analyses of longitudinal data from …

Upon entering a presynaptic terminal, an action potential opens Ca2+ channels, and
transiently increases the local Ca2+ concentration at the presynaptic active zone. Ca2+ then …

Extensive research has yielded crucial insights into the mechanism of neurotransmitter
release, and working models for the functions of key proteins involved in release. The …

Synaptic vesicles are primed into a state that is ready for fast neurotransmitter release upon
Ca 2+-binding to Synaptotagmin-1. This state likely includes trans-SNARE complexes …

Research for three decades and major recent advances have provided crucial insights into
how neurotransmitters are released by Ca2+‐triggered synaptic vesicle exocytosis, leading …

The core of the neurotransmitter release machinery is formed by SNARE complexes, which
bring the vesicle and plasma membranes together and are key for fusion, and by Munc18-1 …

Molecular dynamics simulations of membranes and membrane proteins serve as
computational microscopes, revealing coordinated events at the membrane interface. As G …

This review summarizes current knowledge of synaptic proteins that are central to synaptic
vesicle fusion in presynaptic active zones, including SNAREs (s oluble N-ethylmaleimide …