The synapse in traumatic brain injury

AAB Jamjoom, J Rhodes, PJD Andrews, SGN Grant - Brain, 2021 - academic.oup.com
Traumatic brain injury (TBI) is a leading cause of death and disability worldwide and is a risk
factor for dementia later in life. Research into the pathophysiology of TBI has focused on the …

Translational research in traumatic brain injury

D Laskowitz, G Grant - 2016 - books.google.com
Traumatic brain injury (TBI) remains a significant source of death and permanent disability,
contributing to nearly one-third of all injury related deaths in the United States and exacting …

Repeated mild traumatic brain injury: potential mechanisms of damage

B Fehily, M Fitzgerald - Cell transplantation, 2017 - journals.sagepub.com
Mild traumatic brain injury (mTBI) represents a significant public healthcare concern,
accounting for the majority of all head injuries. While symptoms are generally transient …

Peroxisome proliferator-activated receptor γ (PPARγ): A master gatekeeper in CNS injury and repair

W Cai, T Yang, H Liu, L Han, K Zhang, X Hu… - Progress in …, 2018 - Elsevier
Peroxisome proliferator-activated receptor γ (PPARγ) is a widely expressed ligand-
modulated transcription factor that governs the expression of genes involved in …

White matter involvement after TBI: Clues to axon and myelin repair capacity

RC Armstrong, AJ Mierzwa, CM Marion… - Experimental …, 2016 - Elsevier
Impact-acceleration forces to the head cause traumatic brain injury (TBI) with damage in
white matter tracts comprised of long axons traversing the brain. White matter injury after TBI …

Components of myelin damage and repair in the progression of white matter pathology after mild traumatic brain injury

AJ Mierzwa, CM Marion, GM Sullivan… - … of Neuropathology & …, 2015 - academic.oup.com
White matter tracts are highly vulnerable to damage from impact-acceleration forces of
traumatic brain injury (TBI). Mild TBI is characterized by a low density of traumatic axonal …

Astrocyte‐mediated mechanisms contribute to traumatic brain injury pathology

C Muñoz‐Ballester, S Robel - WIREs mechanisms of disease, 2023 - Wiley Online Library
Astrocytes respond to traumatic brain injury (TBI) with changes to their molecular make‐up
and cell biology, which results in changes in astrocyte function. These changes can be …

[HTML][HTML] White matter damage and degeneration in traumatic brain injury

RC Armstrong, GM Sullivan, DP Perl, JD Rosarda… - Trends in …, 2024 - cell.com
Traumatic brain injury (TBI) is a complex condition that can resolve over time but all too often
leads to persistent symptoms, and the risk of poor patient outcomes increases with aging …

Myelin and oligodendrocyte lineage cells in white matter pathology and plasticity after traumatic brain injury

RC Armstrong, AJ Mierzwa, GM Sullivan… - …, 2016 - Elsevier
Impact to the head or rapid head acceleration–deceleration can cause traumatic brain injury
(TBI) with a characteristic pathology of traumatic axonal injury (TAI) and secondary damage …

Experimental traumatic brain injury identifies distinct early and late phase axonal conduction deficits of white matter pathophysiology, and reveals intervening recovery

CM Marion, KL Radomski, NP Cramer… - Journal of …, 2018 - jneurosci.org
Traumatic brain injury (TBI) patients often exhibit slowed information processing speed that
can underlie diverse symptoms. Processing speed depends on neural circuit function at …