The five-membered pyrrolidine ring is one of the nitrogen heterocycles used widely by
medicinal chemists to obtain compounds for the treatment of human diseases. The great …

The discovery of novel synthetic compounds with drug-like properties is an ongoing
challenge in medicinal chemistry. Natural products have inspired the synthesis of …

Terephthalohydrazide chitosan hydrogel (TCs) was prepared and investigated as an
ecofriendly biopolymeric catalyst for synthesis of some novel thiazole and thiadiazole …

Bacterial infections are a major health problem globally with a continuous increase in death
cases. The drug-resistance problem is associated with the available antibiotics making them …

Microwave-assisted synthesis of numerous bioactive scaffolds has gained much attention of
late in organic chemistry. Most of the heterocyclic rings can be synthesized using the …

The tremendous increase in the bacterial resistance to the available antibiotics is a serious
problem for the treatment of various infections. Biofilm formation in bacteria significantly …

Sortase A (SrtA) is a membrane-associated enzyme that anchors surface-exposed proteins
to the cell wall envelope of Gram-positive bacteria such as Staphylococcus aureus. As SrtA …

Increasingly ineffective antibiotics and rapid spread of multi-and pan-resistant bacteria
represent a global health threat; hence, the need of develo** new antimicrobial …

A new library of peptide-heterocycle hybrids consisting of an indole-3-carboxylic acid
constituent conjugated with short dipeptide motifs was designed and synthesized by using …

Hypothesis Development of nanocomposite coating with antibiofilm properties is of
fundamental importance to efficient fight biofilm formation preventing infections in …