Although diet has long been known to contribute to the pathogenesis of cardiovascular
disease (CVD), research over the past decade has revealed an unexpected interplay …

Background/Aims: Coronary microembolization (CME) is a common complication of acute
coronary syndrome (ACS) and percutaneous coronary intervention (PCI); Myocardial …

Abstract Toll/IL-1R domain-containing adaptor-inducing IFN-β (TRIF)-dependent signaling is
required for TLR-mediated production of type-I IFN and several other proinflammatory …

Mononuclear phagocytes (MPs) relevant to atherosclerosis include monocytes,
macrophages, and dendritic cells. A decade ago, studies on macrophage behavior in …

Atherosclerosis is the major cause of death and disability. Atherosclerotic plaques are
characterized by a chronic sterile inflammation in the large blood vessels, where lipid …

Cardiovascular disease is a leading cause of death worldwide and is associated with
systemic inflammation. In depth study of the cell-specific signaling mechanisms mediating …

TLR4 signalling through the MyD88 and TRIF-dependent pathways initiates translocation of
the transcription factor NF-κB into the nucleus. In cell population studies using mathematical …

Pathogen and nutrient response pathways are evolutionarily conserved and highly
integrated to regulate metabolic and immune homeostasis. Excessive nutrients can be …

The study of the intersection of immunology and metabolism is a growing field fueled by the
increased prevalence of obesity-associated pathologies. Importantly, the capacity of the …

Cardiovascular disease is the leading global health concern and responsible for more
deaths worldwide than any other type of disorder. Atherosclerosis is a chronic inflammatory …