Pancreatic β-cell dysfunction plays an important role in the pathogenesis of both type 1 and
type 2 diabetes. Insulin, which is produced in β-cells, is a critical regulator of metabolism …

Insulin-like growth factor 1 (IGF1) is a peptide growth factor with important functions in
multiple aspects of growth, development and metabolism. The biological actions of IGF1 are …

Insulin, a hormone produced by pancreatic β-cells, has a primary function of maintaining
glucose homeostasis. Deficiencies in β-cell insulin secretion result in the development of …

The insulin-like growth factor 1 (IGF1) signalling pathway has important roles in regulating
cellular proliferation and apoptosis. Converging results from epidemiological research and …

The specificity of cellular responses to receptor stimulation is encoded by the spatial and
temporal dynamics of downstream signalling networks. Temporal dynamics are coupled to …

The insulin-like growth factor (IGF) family of ligands, binding proteins and receptors is an
important growth factor system involved in both the development of the organism and the …

The insulin receptor (IR) is a type II receptor tyrosine kinase that plays essential roles in
metabolism, growth, and proliferation. Dysregulation of IR signaling is linked to many human …

Introduction Cardiovascular (CV) disorders are steadily increasing, making them the world's
most prevalent health issue. New research highlights the importance of insulin-like growth …

Insulin is an anabolic peptide hormone secreted by the b cells of the pancreas acting
through a receptor located in the membrane of target cells-major ones being liver (where it …

The insulin-like growth factor (IGF) signaling pathway consists of multiple IGF ligands, IGF
receptors, and IGF-binding proteins (IGFBPs). Studies in a variety of animal and cellular …