Microbiota-mediated colonization resistance: mechanisms and regulation

G Caballero-Flores, JM Pickard, G Núñez - Nature Reviews …, 2023 - nature.com
A dense and diverse microbial community inhabits the gut and many epithelial surfaces.
Referred to as the microbiota, it co-evolved with the host and is beneficial for many host …

Key determinants of success in fecal microbiota transplantation: From microbiome to clinic

S Porcari, N Benech, M Valles-Colomer, N Segata… - Cell host & …, 2023 - cell.com
Fecal microbiota transplantation (FMT) has achieved satisfactory results in preventing the
recurrence of Clostridioides difficile infection, but these positive outcomes have only been …

[HTML][HTML] Gut microbiota modulation: a novel strategy for prevention and treatment of colorectal cancer

W Fong, Q Li, J Yu - Oncogene, 2020 - nature.com
Research about the role of gut microbiome in colorectal cancer (CRC) is a newly emerging
field of study. Gut microbiota modulation, with the aim to reverse established microbial …

Gut-educated IgA plasma cells defend the meningeal venous sinuses

Z Fitzpatrick, G Frazer, A Ferro, S Clare, N Bouladoux… - Nature, 2020 - nature.com
The central nervous system has historically been viewed as an immune-privileged site, but
recent data have shown that the meninges—the membranes that surround the brain and …

Gut microbiota in the pathogenesis of inflammatory bowel disease

A Nishida, R Inoue, O Inatomi, S Bamba… - Clinical journal of …, 2018 - Springer
Inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, is a
chronic and relapsing inflammatory disorder of the intestine. Although its incidence is …

[HTML][HTML] Mechanism of the gut microbiota colonization resistance and enteric pathogen infection

I Khan, Y Bai, L Zha, N Ullah, H Ullah… - Frontiers in Cellular …, 2021 - frontiersin.org
The mammalian gut microbial community, known as the gut microbiota, comprises trillions of
bacteria, which co-evolved with the host and has an important role in a variety of host …

Gut microbiota: Role in pathogen colonization, immune responses, and inflammatory disease

JM Pickard, MY Zeng, R Caruso… - Immunological …, 2017 - Wiley Online Library
The intestinal tract of mammals is colonized by a large number of microorganisms including
trillions of bacteria that are referred to collectively as the gut microbiota. These indigenous …

Colonocyte metabolism shapes the gut microbiota

Y Litvak, MX Byndloss, AJ Bäumler - Science, 2018 - science.org
BACKGROUND An imbalance in the colonic microbiota might underlie many human
diseases, but the mechanisms that balance our microbial self during homeostasis have long …

A dietary fiber-deprived gut microbiota degrades the colonic mucus barrier and enhances pathogen susceptibility

MS Desai, AM Seekatz, NM Koropatkin, N Kamada… - Cell, 2016 - cell.com
Despite the accepted health benefits of consuming dietary fiber, little is known about the
mechanisms by which fiber deprivation impacts the gut microbiota and alters disease risk …

Intestinal epithelial glycosylation in homeostasis and gut microbiota interactions in IBD

MR Kudelka, SR Stowell, RD Cummings… - Nature reviews …, 2020 - nature.com
Inflammatory bowel disease (IBD) affects 6.8 million people globally. A variety of factors
have been implicated in IBD pathogenesis, including host genetics, immune dysregulation …