This review focuses on fiber optic probes for linear and nonlinear Raman spectroscopy,
especially for medical applications. It aims at providing an overview over contemporary …

Neurological disorders, including spinal cord injury, peripheral nerve injury, traumatic brain
injury, and neurodegenerative diseases, pose significant challenges in terms of diagnosis …

Light-induced toxicity is a fundamental bottleneck in microscopic imaging of live embryos. In
this article, after a review of photodamage mechanisms in cells and tissues, we assess …

Multiphoton imaging has evolved as an indispensable tool in cell biology and holds
prospects for clinical applications. When addressing endogenous signals such as coherent …

Laser microsurgery is a robust method to ablate specific cells in the nervous system and
probe the functional consequences of their loss in the animal. By introducing focal lesions to …

Advancing the practical utility of nonlinear optical microscopy requires continued
improvement in imaging depth and contrast. We evaluated second‐harmonic generation …

The elastic properties of cells are important for many of their functions, however the
development of label free noninvasive cellular elastography method is a challenging topic …

Accurate intraoperative tumour margin assessment is a major challenge in neurooncology,
where sparse tumours beyond the bulk tumour are left undetected under conventional …

Sample health is critical for live-cell fluorescence microscopy and has promoted light-sheet
microscopy that restricts its ultraviolet-visible excitation to one plane inside a three …

Ultrashort femtosecond pulsed lasers may provide indispensable benefits for medical
bioimaging and diagnosis, particularly for noninvasive biopsy. However, the ability of …