Autophagy is a common name for a number of catabolic processes, which keep the cellular
homeostasis by removing damaged and dysfunctional intracellular components. Impairment …

Cellular survival hinges on a delicate balance between accumulating damages and repair
mechanisms. In this intricate equilibrium, oxidants, currently considered physiological …

Autophagy is an essential catabolic pathway which sequesters and engulfs cytosolic
substrates via autophagosomes, unique double-membraned structures. ATG8 proteins are …

Reliable prediction of free energy changes upon amino acid substitutions (ΔΔ G s) is crucial
to investigate their impact on protein stability and protein–protein interaction. Advances in …

The spike protein of SARS-CoV-2 binds the angiotensin-converting enzyme 2 (ACE2) on the
host cell surface and subsequently enters host cells through receptor-mediated endocytosis …

Since 2003, the world has been confronted with three new betacoronaviruses that cause
human respiratory infections: SARS-CoV, which causes severe acute respiratory syndrome …

Research in biomedical sciences has changed dramatically over the past fifty years. There is
no doubt that the discovery of apoptosis and autophagy as two highly synchronized and …

A major hallmark of Parkinson's disease (PD) is the fatal destruction of dopaminergic
neurons within the substantia nigra pars compacta. This event is preceded by the formation …

Ksp1 is a casein II-like kinase whose activity prevents aberrant macroautophagy/autophagy
induction in nutrient-rich conditions in yeast. Here, we describe a kinase-independent role of …

The ischemia and hypoxia microenvironment after spinal cord injury (SCI) makes SCI repair
a challenging problem. With various stimulus, chances for neural stem cells (NSCs) to …