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Cocrystals by design: a rational coformer selection approach for tackling the API problems
Active pharmaceutical ingredients (API) with unfavorable physicochemical properties and
stability present a significant challenge during their processing into final dosage forms …
stability present a significant challenge during their processing into final dosage forms …
Hydrophilic Cocrystals with Water Switched Luminescence
Utilizing water molecules to regulate the luminescence properties of solid materials is highly
challenging. Herein, we develop a strategy to produce water‐triggered luminescence …
challenging. Herein, we develop a strategy to produce water‐triggered luminescence …
Crystalline multicomponent solids: An alternative for addressing the hygroscopicity issue in pharmaceutical materials
The ambient humidity varies with seasons and geographical altitude across the regions. A
change in relative humidity during processing, storage, and transportation can cause …
change in relative humidity during processing, storage, and transportation can cause …
Can we identify the salt–cocrystal continuum state using XPS?
X-ray photoelectron spectroscopy (XPS) is used to understand the nature of acid–base
crystalline solids, to know whether the product is a salt (proton transfer, O–··· H–N+) or a …
crystalline solids, to know whether the product is a salt (proton transfer, O–··· H–N+) or a …
Green and efficient delivery of pesticides throughout their life cycle via cooperative solid and solution self-assembly
Y **ao, C Wu, S Feng, M Chen, H Cao, K Chen… - Chemical Engineering …, 2023 - Elsevier
Addressing the economic and environmental challenges posed by non-target losses
throughout the pesticide life cycle necessitates a simple, yet effective strategy. In this work, a …
throughout the pesticide life cycle necessitates a simple, yet effective strategy. In this work, a …
Progress on cocrystallization of poorly soluble NME's in the last decade
For tailoring the physicochemical properties of active pharmaceutical ingredients,
cocrystallization has been an exciting field of interest to the researchers. As in recent years …
cocrystallization has been an exciting field of interest to the researchers. As in recent years …
Biocompatible Nano-Cocrystal Engineering for Targeted Herbicide Delivery: Enhancing Efficacy through Stimuli-Responsive Release and Reduced Environmental …
Y **ao, C Wu, Y Liu, L Zhou, S Wu… - ACS Applied Materials & …, 2024 - ACS Publications
In addressing the critical challenges posed by the misuse and inefficiency of traditional
pesticides, we introduce a Nano-Cocrystal material composed of the herbicide clopyralid …
pesticides, we introduce a Nano-Cocrystal material composed of the herbicide clopyralid …
[HTML][HTML] Preparation, characterization, and pharmacokinetics of rivaroxaban cocrystals with enhanced in vitro and in vivo properties in beagle dogs
Y Meng, F Tan, J Yao, Y Cui, Y Feng, Z Li… - International Journal of …, 2022 - Elsevier
Rivaroxaban (RIV) is a direct Factor Xa inhibitor anticoagulant, but the oral bioavailability of
RIV is estimated to be only 60% due to its poor solubility. The aim of the present study was to …
RIV is estimated to be only 60% due to its poor solubility. The aim of the present study was to …
Measurement and correlation of solubility of rivaroxaban in dichloromethane and primary alcohol binary solvent mixtures at different temperatures
The solubility of rivaroxaban in different solvent mixtures consisting of dichloromethane and
primary alcohols, including methanol, ethanol, n-propanol, and n-butanol, was evaluated …
primary alcohols, including methanol, ethanol, n-propanol, and n-butanol, was evaluated …
Surface characterization of pharmaceutical solids
Surface properties alter solid-solid and solid-liquid interfacial interactions that profoundly
impact manufacturability, processability, dissolution kinetics and stability of pharmaceutical …
impact manufacturability, processability, dissolution kinetics and stability of pharmaceutical …