Managing the immune microenvironment of osteosarcoma: the outlook for osteosarcoma treatment

H Tian, J Cao, B Li, EC Nice, H Mao, Y Zhang… - Bone Research, 2023 - nature.com
Osteosarcoma, with poor survival after metastasis, is considered the most common primary
bone cancer in adolescents. Notwithstanding the efforts of researchers, its five-year survival …

Osteosarcoma and metastasis

G Sheng, Y Gao, Y Yang, H Wu - Frontiers in oncology, 2021 - frontiersin.org
Osteosarcoma is the most common primary bone malignancy in adolescents. Its high
propensity to metastasize is the leading cause for treatment failure and poor prognosis …

Anti–spike IgG causes severe acute lung injury by skewing macrophage responses during acute SARS-CoV infection

L Liu, Q Wei, Q Lin, J Fang, H Wang, H Kwok… - JCI …, 2019 - pmc.ncbi.nlm.nih.gov
Newly emerging viruses, such as severe acute respiratory syndrome coronavirus (SARS-
CoV), Middle Eastern respiratory syndrome CoVs (MERS-CoV), and H7N9, cause fatal …

[HTML][HTML] Tumor-associated macrophages in osteosarcoma: from mechanisms to therapy

F Cersosimo, S Lonardi, G Bernardini, B Telfer… - International journal of …, 2020 - mdpi.com
Osteosarcomas (OSs) are bone tumors most commonly found in pediatric and adolescent
patients characterized by high risk of metastatic progression and recurrence after therapy …

Immune infiltration and PD-L1 expression in the tumor microenvironment are prognostic in osteosarcoma

P Koirala, ME Roth, J Gill, S Piperdi, JM Chinai… - Scientific reports, 2016 - nature.com
Osteosarcoma patient survival has remained stagnant for 30 years. Novel therapeutic
approaches are needed to improve outcomes. We examined the expression of Programmed …

The contribution of immune infiltrates and the local microenvironment in the pathogenesis of osteosarcoma

MF Heymann, F Lézot, D Heymann - Cellular immunology, 2019 - Elsevier
Osteosarcoma is a rare primary bone cancer characterized by cancer cells producing
calcified osteoid extracellular matrix and inducing lung metastases with a high frequency …

Single-cell transcriptomics reveals the complexity of the tumor microenvironment of treatment-naive osteosarcoma

Y Liu, W Feng, Y Dai, M Bao, Z Yuan, M He… - Frontiers in …, 2021 - frontiersin.org
Osteosarcoma (OS), which occurs most commonly in adolescents, is associated with a high
degree of malignancy and poor prognosis. In order to develop an accurate treatment for OS …

Anti‐PD‐1 therapy redirects macrophages from an M2 to an M1 phenotype inducing regression of OS lung metastases

P Dhupkar, N Gordon, J Stewart… - Cancer …, 2018 - Wiley Online Library
Osteosarcoma (OS) pulmonary metastasis translates into poor patient survival. The
implication of PD‐1‐PD‐L1 pathway in the context of NK cells and/or macrophages in OS is …

The role of tumor-associated macrophages in osteosarcoma progression–therapeutic implications

Q Huang, X Liang, T Ren, Y Huang, H Zhang, Y Yu… - Cellular Oncology, 2021 - Springer
Background Osteosarcoma (OS) is the most common primary malignant bone tumor.
Compared with previous treatment modalities, such as amputation, more recent …

CD163-positive tumor-associated macrophages and CD8-positive cytotoxic lymphocytes are powerful diagnostic markers for the therapeutic stratification of …

A Gomez-Brouchet, C Illac, J Gilhodes… - …, 2017 - Taylor & Francis
The French phase 3 trial (OS 2006) testing zoledronic acid, an osteoclast inhibitor, with
chemotherapy and surgery did not improve the outcome of patients with osteosarcoma (OS) …