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Managing the immune microenvironment of osteosarcoma: the outlook for osteosarcoma treatment
Osteosarcoma, with poor survival after metastasis, is considered the most common primary
bone cancer in adolescents. Notwithstanding the efforts of researchers, its five-year survival …
bone cancer in adolescents. Notwithstanding the efforts of researchers, its five-year survival …
Osteosarcoma and metastasis
Osteosarcoma is the most common primary bone malignancy in adolescents. Its high
propensity to metastasize is the leading cause for treatment failure and poor prognosis …
propensity to metastasize is the leading cause for treatment failure and poor prognosis …
Anti–spike IgG causes severe acute lung injury by skewing macrophage responses during acute SARS-CoV infection
Newly emerging viruses, such as severe acute respiratory syndrome coronavirus (SARS-
CoV), Middle Eastern respiratory syndrome CoVs (MERS-CoV), and H7N9, cause fatal …
CoV), Middle Eastern respiratory syndrome CoVs (MERS-CoV), and H7N9, cause fatal …
[HTML][HTML] Tumor-associated macrophages in osteosarcoma: from mechanisms to therapy
F Cersosimo, S Lonardi, G Bernardini, B Telfer… - International journal of …, 2020 - mdpi.com
Osteosarcomas (OSs) are bone tumors most commonly found in pediatric and adolescent
patients characterized by high risk of metastatic progression and recurrence after therapy …
patients characterized by high risk of metastatic progression and recurrence after therapy …
Immune infiltration and PD-L1 expression in the tumor microenvironment are prognostic in osteosarcoma
Osteosarcoma patient survival has remained stagnant for 30 years. Novel therapeutic
approaches are needed to improve outcomes. We examined the expression of Programmed …
approaches are needed to improve outcomes. We examined the expression of Programmed …
The contribution of immune infiltrates and the local microenvironment in the pathogenesis of osteosarcoma
Osteosarcoma is a rare primary bone cancer characterized by cancer cells producing
calcified osteoid extracellular matrix and inducing lung metastases with a high frequency …
calcified osteoid extracellular matrix and inducing lung metastases with a high frequency …
Single-cell transcriptomics reveals the complexity of the tumor microenvironment of treatment-naive osteosarcoma
Y Liu, W Feng, Y Dai, M Bao, Z Yuan, M He… - Frontiers in …, 2021 - frontiersin.org
Osteosarcoma (OS), which occurs most commonly in adolescents, is associated with a high
degree of malignancy and poor prognosis. In order to develop an accurate treatment for OS …
degree of malignancy and poor prognosis. In order to develop an accurate treatment for OS …
Anti‐PD‐1 therapy redirects macrophages from an M2 to an M1 phenotype inducing regression of OS lung metastases
Osteosarcoma (OS) pulmonary metastasis translates into poor patient survival. The
implication of PD‐1‐PD‐L1 pathway in the context of NK cells and/or macrophages in OS is …
implication of PD‐1‐PD‐L1 pathway in the context of NK cells and/or macrophages in OS is …
The role of tumor-associated macrophages in osteosarcoma progression–therapeutic implications
Q Huang, X Liang, T Ren, Y Huang, H Zhang, Y Yu… - Cellular Oncology, 2021 - Springer
Background Osteosarcoma (OS) is the most common primary malignant bone tumor.
Compared with previous treatment modalities, such as amputation, more recent …
Compared with previous treatment modalities, such as amputation, more recent …
CD163-positive tumor-associated macrophages and CD8-positive cytotoxic lymphocytes are powerful diagnostic markers for the therapeutic stratification of …
A Gomez-Brouchet, C Illac, J Gilhodes… - …, 2017 - Taylor & Francis
The French phase 3 trial (OS 2006) testing zoledronic acid, an osteoclast inhibitor, with
chemotherapy and surgery did not improve the outcome of patients with osteosarcoma (OS) …
chemotherapy and surgery did not improve the outcome of patients with osteosarcoma (OS) …