Misinterpretation of the mouse ECG: 'musing the waves of Mus musculus'

BJ Boukens, MR Rivaud, S Rentschler… - The Journal of …, 2014 - Wiley Online Library
The ECG is a primary diagnostic tool in patients suffering from heart disease, underscoring
the importance of understanding factors contributing to normal and abnormal electrical …

Murine electrophysiological models of cardiac arrhythmogenesis

CLH Huang - Physiological reviews, 2017 - journals.physiology.org
Cardiac arrhythmias can follow disruption of the normal cellular electrophysiological
processes underlying excitable activity and their tissue propagation as coherent wavefronts …

[HTML][HTML] A circadian clock in the sinus node mediates day-night rhythms in Hcn4 and heart rate

A D'souza, Y Wang, C Anderson, A Bucchi… - Heart rhythm, 2021 - Elsevier
Background Heart rate follows a diurnal variation, and slow heart rhythms occur primarily at
night. Objective The lower heart rate during sleep is assumed to be neural in origin, but here …

[HTML][HTML] Control of ventricular excitability by neurons of the dorsal motor nucleus of the vagus nerve

A Machhada, R Ang, GL Ackland, N Ninkina… - Heart rhythm, 2015 - Elsevier
Background The central nervous origins of functional parasympathetic innervation of cardiac
ventricles remain controversial. Objective This study aimed to identify a population of vagal …

Guidelines for assessing maternal cardiovascular physiology during pregnancy and postpartum

HE Collins, BT Alexander, AS Care… - American Journal …, 2024 - journals.physiology.org
Maternal mortality rates are at an all-time high across the world and are set to increase in
subsequent years. Cardiovascular disease is the leading cause of death during pregnancy …

The electrocardiogram of vertebrates: Evolutionary changes from ectothermy to endothermy

BJD Boukens, DL Kristensen, R Filogonio… - Progress in biophysics …, 2019 - Elsevier
The electrocardiogram (ECG) reveals that heart chamber activation and repolarization are
much faster in mammals and birds compared to ectothermic vertebrates of similar size …

Experimental hypothyroidism induces cardiac arrhythmias and ranolazine reverts and prevents the phenotype

DS Souza, LP Marques, AD Costa, JS Cruz, P Rhana… - Life Sciences, 2022 - Elsevier
Aims Hypothyroidism is associated with an increased risk of cardiovascular disease and
enhanced susceptibility to arrhythmias. In our investigation, we evaluated the potential …

The complex QT/RR relationship in mice

J Roussel, P Champeroux, J Roy, S Richard… - Scientific reports, 2016 - nature.com
The QT interval reflects the time between the depolarization of ventricles until their
repolarization and is usually used as a predictive marker for the occurrence of arrhythmias …

Cardiac natriuretic peptide deficiency sensitizes the heart to stress-induced ventricular arrhythmias via impaired CREB signalling

EJ Hall, S Pal, MS Glennon, P Shridhar… - Cardiovascular …, 2022 - academic.oup.com
Aims The cardiac natriuretic peptides [atrial natriuretic peptide (ANP) and B-type natriuretic
peptide (BNP)] are important regulators of cardiovascular physiology, with reduced …

Feeding behavior modifies the circadian variation in RR and QT intervals by distinct mechanisms in mice

M Ono, DE Burgess, SR Johnson… - American Journal …, 2024 - journals.physiology.org
Rhythmic feeding behavior is critical for regulating phase and amplitude in the≈ 24-h
variation of heart rate (RR intervals), ventricular repolarization (QT intervals), and core body …