The controlled drug delivery of hydrophilic and lipophilic drug substances via the parenteral
route has gained increasing importance in the development of pharmaceutical dosage …

When methods of drug intervention are being developed to control estrous cycles, a
thorough understanding of the endocrine and functional changes together with the …

In this paper some of the latest studies and research works conducted on SILICONE based
DRUG DELIVERY SYSTEMS (DDS) are reviewed and some of more specific and important …

The purpose of this study was to reengineer a commercially available intravaginal insert
containing 1.9 g progesterone (CIDR intravaginal insert) for a 7-day insertion period in …

Objectives were to compare circulating progesterone (P4) profile and pregnancies per AI
(P/AI) of two commercial intravaginal P4 devices (PRID-Delta® vs CIDR®). In Experiment 1 …

Poly (ortho esters)(POE) are hydrophobic and bioerodible polymers that have been
investigated for pharmaceutical use since the early 1970s. Among the four described …

Commercially available intravaginal progesterone (P4) devices differ in shape, surface area
and P4 load, which may affect the resulting pregnancy per AI (P/AI) following timed-AI (TAI) …

The aim of this study was to investigate the relationship between different estrus
synchronization protocols, some fertility parameters and serum biochemical parameters …

In the veterinary field, the development of new routes of administration or new delivery
systems capable of controlling the release of drugs are of considerable interest. Because of …

5.12. 2 The Human Vagina 5.12. 2.1 Anatomy 5.12. 2.2 Histology 5.12. 2.3 Physiology 5.12.
2.4 Childhood, Pregnancy, and Menopause 5.12. 3 General Features of Vaginal Drug …