Distilling biologically meaningful information from cancer genome sequencing data requires
comprehensive identification of somatic alterations using rigorous computational methods …

Germline copy number variants (CNVs) and somatic copy number alterations (SCNAs) are
of significant importance in syndromic conditions and cancer. Massively parallel sequencing …

Bioinformatics pipelines are essential in the analysis of genomic and transcriptomic data
generated by next-generation sequencing (NGS). Recent guidelines emphasize the need …

We performed proteogenomic characterization of intrahepatic cholangiocarcinoma (iCCA)
using paired tumor and adjacent liver tissues from 262 patients. Integrated proteogenomic …

Glioblastoma (GBM) is a devastating and incurable brain tumour, with a median overall
survival of fifteen months,. Identifying the cell of origin that harbours mutations that drive …

We performed the first proteogenomic study on a prospectively collected colon cancer
cohort. Comparative proteomic and phosphoproteomic analysis of paired tumor and normal …

Human epithelial tissues accumulate cancer-driver mutations with age,,,,,,,–, yet tumour
formation remains rare. The positive selection of these mutations suggests that they alter the …

We present an exceptional case of a patient with high-grade serous ovarian cancer, treated
with multiple chemotherapy regimens, who exhibited regression of some metastatic lesions …

The inter-and intra-tumor heterogeneity of breast cancer needs to be adequately captured in
pre-clinical models. We have created a large collection of breast cancer patient-derived …

Tumor organoids are 3D cultures of cancer cells. They can be derived from the tumor of
each individual patient, thereby providing an attractive ex vivo assay to tailor treatment …