[HTML][HTML] Exercise, GLUT4, and skeletal muscle glucose uptake

EA Richter, M Hargreaves - Physiological reviews, 2013 - journals.physiology.org
Glucose is an important fuel for contracting muscle, and normal glucose metabolism is vital
for health. Glucose enters the muscle cell via facilitated diffusion through the GLUT4 glucose …

Physiological and health implications of a sedentary lifestyle

MS Tremblay, RC Colley, TJ Saunders… - Applied physiology …, 2010 - cdnsciencepub.com
Sedentary behaviour is associated with deleterious health outcomes, which differ from those
that can be attributed to a lack of moderate to vigorous physical activity. This has led to the …

Membrane fatty acid transporters as regulators of lipid metabolism: implications for metabolic disease

JFC Glatz, JJFP Luiken, A Bonen - Physiological reviews, 2010 - journals.physiology.org
Long-chain fatty acids and lipids serve a wide variety of functions in mammalian
homeostasis, particularly in the formation and dynamic properties of biological membranes …

[HTML][HTML] AMPK and PPARδ agonists are exercise mimetics

VA Narkar, M Downes, TY Ruth, E Embler, YX Wang… - Cell, 2008 - cell.com
The benefits of endurance exercise on general health make it desirable to identify orally
active agents that would mimic or potentiate the effects of exercise to treat metabolic …

Adaptations of skeletal muscle to exercise: rapid increase in the transcriptional coactivator PGC‐1

K Baar, AR Wende, TE Jones, M Marison… - The FASEB …, 2002 - Wiley Online Library
Endurance exercise induces increases in mitochondria and the GLUT4 isoform of the
glucose transporter in muscle. Although little is known about the mechanisms underlying …

Facilitative glucose transporters

M Mueckler - European journal of biochemistry, 1994 - Wiley Online Library
Facilitative glucose transport is mediated by members of the Glut protein family that belong
to a much larger superfamily of 12 transmembrane segment transporters. Six members of …

Exercise and insulin sensitivity: a review

LB Borghouts, HA Keizer - International journal of sports …, 2000 - thieme-connect.com
Physical activity has been advocated in the treatment of diabetes mellitus from as early as
the 5th century [116]. More recent epidemiological studies have provided evidence that the …

Signaling pathways in skeletal muscle remodeling

R Bassel-Duby, EN Olson - Annu. Rev. Biochem., 2006 - annualreviews.org
Skeletal muscle is comprised of heterogeneous muscle fibers that differ in their physiological
and metabolic parameters. It is this diversity that enables different muscle groups to provide …

Molecular and cellular adaptation of muscle in response to exercise: perspectives of various models

FW Booth, DB Thomason - Physiological reviews, 1991 - journals.physiology.org
542 FRANK W. BOOTH AND DONALD B. THOMASON Volume 71 emphasized that
biochemical and physiological adaptations to a changed environment or physiological …

PGC-1α regulation by exercise training and its influences on muscle function and insulin sensitivity

VA Lira, CR Benton, Z Yan… - American Journal of …, 2010 - journals.physiology.org
The peroxisome proliferator-activated receptor-γ (PPARγ) coactivator-1α (PGC-1α) is a
major regulator of exercise-induced phenotypic adaptation and substrate utilization. We …