Apoptosis has been extensively studied, whereas ferroptosis is a newly discovered form of
regulated cell death that involves iron‐dependent accumulations of lipid hydroperoxides …

Free radicals, generally composed of reactive oxygen species (ROS) and reactive nitrogen
species (RNS), are generated in the body by various endogenous and exogenous systems …

Significance: Glutathione (GSH) depletion is a central signaling event that regulates the
activation of cell death pathways. GSH depletion is often taken as a marker of oxidative …

Curcumin has attracted increasing interest as an anti-cancer drug for decades. The
mechanisms of action involve multiple cancer-related signaling pathways. Recent studies …

Glutathione (GSH) has a crucial role in cellular signaling and antioxidant defenses either by
reacting directly with reactive oxygen or nitrogen species or by acting as an essential …

Regulated cell death (RCD) refers to the form of cell death that can be regulated by various
biomacromolecules. Each cell death modalities have their distinct morphological changes …

Diabetes mellitus is a metabolic disease with multiple complications that causes serious
diseases over the years. The condition leads to severe economic consequences and is …

Ceramide is synthesized upon stimuli, and induces apoptosis in renal tubular cells (RTCs).
Sphingosine-1 phosphate (S1P) functions as a survival factor. Thus, the balance of …

Studies over the past two decades have identified ceramide as a multifunctional central
molecule in the sphingolipid biosynthetic pathway. Given its diverse tumor suppressive …

Polyphenols, chemically characterized by a polyhydroxylated phenolic structure, are well
known for their widespread pharmacological properties: anti-inflammatory, antibiotic …