Lipid droplets in neurodegenerative disorders
BC Farmer, AE Walsh, JC Kluemper… - Frontiers in …, 2020 - frontiersin.org
Knowledge of lipid droplets (LDs) has evolved from simple depots of lipid storage to
dynamic and functionally active organelles involved in a variety of cellular functions. Studies …
dynamic and functionally active organelles involved in a variety of cellular functions. Studies …
[HTML][HTML] Role of Lipid Droplets in Neurodegenerative Diseases: From Pathogenesis to Therapeutics
Y Kang, YJ Yeap, J Yang, S Ma, KL Lim… - Neuroscience & …, 2024 - Elsevier
Neurodegenerative diseases (NDDs) are a series of disorders characterized by the
progressive loss of specific neurons, leading to cognitive and locomotor impairment. NDDs …
progressive loss of specific neurons, leading to cognitive and locomotor impairment. NDDs …
Multiscale label-free imaging of myelin in human brain tissue with polarization-sensitive optical coherence tomography and birefringence microscopy
N Blanke, S Chang, A Novoseltseva… - Biomedical Optics …, 2023 - opg.optica.org
The combination of polarization-sensitive optical coherence tomography (PS-OCT) and
birefringence microscopy (BRM) enables multiscale assessment of myelinated axons in …
birefringence microscopy (BRM) enables multiscale assessment of myelinated axons in …
Oleic acid is a potent inducer for lipid droplet accumulation through its esterification to glycerol by diacylglycerol acyltransferase in primary cortical astrocytes
S Nakajima, M Gotoh, K Fukasawa… - Brain Research, 2019 - Elsevier
Astrocytes exhibit an important role in neural lipid metabolism for the regulation of energy
balance to supply fatty acids (FAs) and ketone bodies to other neural cells. Lipid droplets …
balance to supply fatty acids (FAs) and ketone bodies to other neural cells. Lipid droplets …
Raman spectroscopy and neuroscience: from fundamental understanding to disease diagnostics and imaging
TD Payne, AS Moody, AL Wood, PA Pimiento, JC Elliott… - Analyst, 2020 - pubs.rsc.org
Neuroscience would directly benefit from more effective detection techniques, leading to
earlier diagnosis of disease. The specificity of Raman spectroscopy is unparalleled, given …
earlier diagnosis of disease. The specificity of Raman spectroscopy is unparalleled, given …
Myelin injury in the central nervous system and Alzheimer's disease
SS Wang, Z Zhang, TB Zhu, SF Chu, WB He… - Brain Research …, 2018 - Elsevier
Myelin is a membrane wrapped around the axon of the nerve cell, which is composed of the
mature oligodendrocytes. The role of myelin is to insulate and prevent the nerve electrical …
mature oligodendrocytes. The role of myelin is to insulate and prevent the nerve electrical …
Quantitative birefringence microscopy for imaging the structural integrity of CNS myelin following circumscribed cortical injury in the rhesus monkey
Significance: Myelin breakdown is likely a key factor in the loss of cognitive and motor
function associated with many neurodegenerative diseases. Aim: New methods for imaging …
function associated with many neurodegenerative diseases. Aim: New methods for imaging …
[HTML][HTML] Contribution of intravital neuroimaging to study animal models of multiple sclerosis
E Buttigieg, A Scheller, B El Waly, F Kirchhoff… - …, 2023 - Elsevier
Multiple sclerosis (MS) is a complex and long-lasting neurodegenerative disease of the
central nervous system (CNS), characterized by the loss of myelin within the white matter …
central nervous system (CNS), characterized by the loss of myelin within the white matter …
Coherent anti-Stokes Raman spectroscopy (CARS) application for imaging myelination in brain slices
EA McCullagh, S Poleg, D Stich… - Journal of visualized …, 2022 - pmc.ncbi.nlm.nih.gov
Coherent anti-Stokes Raman spectroscopy (CARS) is a technique classically employed by
chemists and physicists to produce a coherent signal of signature vibrations of molecules …
chemists and physicists to produce a coherent signal of signature vibrations of molecules …
Intranasal delivery of SDF‐1α‐preconditioned bone marrow mesenchymal cells improves remyelination in the cuprizone‐induced mouse model of multiple sclerosis
F Beigi Boroujeni, P Pasbakhsh… - Cell biology …, 2020 - Wiley Online Library
Multiple sclerosis (MS) is an inflammatory and demyelinating disease of the central nervous
system (CNS) that leads to disability in middle‐aged individuals. High rates of apoptosis and …
system (CNS) that leads to disability in middle‐aged individuals. High rates of apoptosis and …