The microtubule-based spindle orchestrates chromosome segregation during cell division.
Following more than a century of study, many components and pathways contributing to …

The mitotic spindle has a crucial role in ensuring the accurate segregation of chromosomes
into the two daughter cells during cell division, which is paramount for maintaining genome …

Microtubules are one of the major cytoskeletal components of neurons, essential for many
fundamental cellular and developmental processes, such as neuronal migration, polarity …

It has become clear that the role of centrosomes extends well beyond that of important
microtubule organizers. There is increasing evidence that they also function as coordination …

The centrosome is the primary microtubule organizing center of the cells and templates the
formation of cilia, thereby operating at a nexus of critical cellular functions. Here, we use …

Phase separation of substrates and effectors is proposed to enhance biological reaction
rates and efficiency. Targeting protein for Xklp2 (TPX2) is an effector of branching …

Execution of the DNA damage response (DDR) relies upon a dynamic array of protein
modifications. Using quantitative proteomics, we have globally profiled ubiquitination …

Microtubule nucleation is regulated by the γ-tubulin ring complex (γTuRC) and related γ-
tubulin complexes, providing spatial and temporal control over the initiation of microtubule …

Recent advances in next generation sequencing,,, have made it possible to precisely
characterize all somatic coding mutations that occur during the development and …

The organization of microtubule networks is crucial for controlling chromosome segregation
during cell division, for positioning and transport of different organelles, and for cell polarity …