Clinical implications of glyoxalase1 gene polymorphism and elevated levels of the reactive...

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Glyoxalase System in Breast and Ovarian Cancers: Role of MEK/ERK/SMAD1 Pathway‏

M Alhujaily - Biomolecules, 2024‏ - mdpi.com‏
The glyoxalase system, comprising GLO1 and GLO2 enzymes, is integral in detoxifying
methylglyoxal (MGO) generated during glycolysis, with dysregulation implicated in various …‏
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The genetic polymorphisms and activity of glyoxalase 1 as a risk factor for acute coronary syndrome in South Indians with type 2 diabetes mellitus‏

S Bora, PS Adole, KV Vinod, AA Pillai, S Ahmed - Gene, 2023‏ - Elsevier‏
Objective The individuals' genetic traits predispose them to a higher or lower risk of Type 2
diabetes mellitus (T2DM) and its complications, for example, acute coronary syndrome …‏
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Association between GLO1 variants and gestational diabetes mellitus susceptibility in a Chinese population: a preliminary study‏

Q Zeng, T Yang, W Wei, D Zou, Y Wei, F Han… - Frontiers in …, 2023‏ - frontiersin.org‏
Background Glyoxalase 1 (GLO1) plays a crucial role in defending against glycation. Single
nucleotide polymorphism (SNP) variants in the GLO1 gene may affect gene expression and …‏
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Genetic polymorphism of glyoxalase I gene (A419C and C-7 T) and nephropathy risk in patients with type 2 diabetes mellitus among north Indian population: a case …‏

M Nachimuthu, T Kanwar, M Rathore, K Sreenivasulu… - Human Gene, 2024‏ - Elsevier‏
Background The global burden of Diabetic nephropathy is rising and eventually leads to
chronic kidney disease. Methylglyoxal (MGO) is an antecedent to advanced glycation end …‏
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[HTML][HTML] Determination of Glyoxalase-1 levels and Identification of Genetic Variants in GLO1 Gene in Patients of Diabetic Nephropathy‏

SZH Shah, A Rashid, A Majeed - Pakistan Journal of Medical …, 2024‏ - ncbi.nlm.nih.gov‏
Objective: To determine the association of diabetic nephropathy with glyoxalase-1 enzyme
levels and a genetic missense variation (SNP rs4746) in its gene (GLO-1). Methods: This …‏
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