Facing the explosive growth of biological sequence data, such as those of protein/peptide
and DNA/RNA, generated in the post-genomic age, many bioinformatical and mathematical …

The eternal or ultimate goal of medicinal chemistry is to find most effective ways to treat
various diseases and extend human beings' life as long as possible. Human being is a …

Motivation Being responsible for initiating transaction of a particular gene in genome,
promoter is a short region of DNA. Promoters have various types with different functions …

Cancer remains a major killer worldwide. Traditional methods of cancer treatment are
expensive and have some deleterious side effects on normal cells. Fortunately, the …

With the avalanche of DNA/RNA sequences generated in the post-genomic age, it is urgent
to develop automated methods for analyzing the relationship between the sequences and …

Involved with important cellular or gene functions and implicated with many kinds of cancers,
piRNAs, or piwi-interacting RNAs, are of small non-coding RNA with around 19–33 nt in …

Pse-in-One 2.0 is a package of web-servers evolved from Pse-in-One (Liu, B., Liu, F., Wang,
X., Chen, J. Fang, L. & Chou, KC Nucleic Acids Research, 2015, 43: W65-W71). In order to …

Background: Thermophilic proteins can maintain good activity under high temperature,
therefore, it is important to study thermophilic proteins for the thermal stability of proteins …

A cell contains thousands of proteins. Many important functions of cell are carried out
through the proteins therein. Proteins rarely function alone. Most of their functions essential …

Predominantly occurring on cytosine, DNA methylation is a process by which cells can
modify their DNAs to change the expression of gene products. It plays very important roles in …