Inflammaging and osteoarthritis

F Motta, E Barone, A Sica, C Selmi - Clinical reviews in allergy & …, 2023 - Springer
Osteoarthritis is a highly prevalent disease particularly in subjects over 65 years of age
worldwide. While in the past it was considered a mere consequence of cartilage degradation …

Knee osteoarthritis: a review of pathogenesis and state-of-the-art non-operative therapeutic considerations

D Primorac, V Molnar, E Rod, Ž Jeleč, F Čukelj… - Genes, 2020 - mdpi.com
Being the most common musculoskeletal progressive condition, osteoarthritis is an
interesting target for research. It is estimated that the prevalence of knee osteoarthritis (OA) …

Silk fibroin-based biomaterials for cartilage/osteochondral repair

Z Zhou, J Cui, S Wu, Z Geng, J Su - Theranostics, 2022 - pmc.ncbi.nlm.nih.gov
Osteoarthritis (OA) is a common joint disease with a high disability rate. In addition, OA not
only causes great physiological and psychological harm to patients, but also puts great …

Benefits and mechanisms of exercise training for knee osteoarthritis

CY Zeng, ZR Zhang, ZM Tang, FZ Hua - Frontiers in physiology, 2021 - frontiersin.org
Knee osteoarthritis is a chronic degenerative disease. Cartilage and subchondral bone
degeneration, as well as synovitis, are the main pathological changes associated with knee …

The role of inflammation in the pathogenesis of osteoarthritis

YY Chow, KY Chin - Mediators of inflammation, 2020 - Wiley Online Library
A joint is the point of connection between two bones in our body. Inflammation of the joint
leads to several diseases, including osteoarthritis, which is the concern of this review …

Targeting cell death: pyroptosis, ferroptosis, apoptosis and necroptosis in osteoarthritis

J Yang, S Hu, Y Bian, J Yao, D Wang, X Liu… - Frontiers in cell and …, 2022 - frontiersin.org
New research has shown that the development of osteoarthritis (OA) is regulated by different
mechanisms of cell death and types of cytokines. Therefore, elucidating the mechanism of …

Microenvironment in subchondral bone: predominant regulator for the treatment of osteoarthritis

W Hu, Y Chen, C Dou, S Dong - Annals of the rheumatic diseases, 2021 - Elsevier
Osteoarthritis (OA) is a degenerative joint disease in the elderly. Although OA has been
considered as primarily a disease of the articular cartilage, the participation of subchondral …

Cartilage tissue engineering: From proinflammatory and anti-inflammatory cytokines to osteoarthritis treatments

S Liu, Z Deng, K Chen, S Jian… - Molecular …, 2022 - spandidos-publications.com
Osteoarthritis (OA), one of the most common joint diseases, is characterized by fibrosis,
rhagadia, ulcers and attrition of articular cartilage due to a number of factors. The etiology of …

The regulation of cartilage extracellular matrix homeostasis in joint cartilage degeneration and regeneration

Z Peng, H Sun, V Bunpetch, Y Koh, Y Wen, D Wu… - Biomaterials, 2021 - Elsevier
Osteoarthritis (OA) is a major cause of disability and socioeconomic loss worldwide.
However, the current pharmacological approaches used to treat OA are largely palliative …

Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis

WH Robinson, CM Lepus, Q Wang, H Raghu… - Nature Reviews …, 2016 - nature.com
Osteoarthritis (OA) has long been viewed as a degenerative disease of cartilage, but
accumulating evidence indicates that inflammation has a critical role in its pathogenesis …