We describe the CoMet application for large-scale epistatic Genome-Wide Association
Studies (eGWAS) and pleiotropy studies. High performance is attained by transforming the …

Motivation The existing epistasis analysis approaches have been criticized mainly for
their:(i) ignoring heterogeneity during epistasis analysis;(ii) high computational costs; and …

epiSNP is a program for identifying pairwise single nucleotide polymorphism (SNP)
interactions (epistasis) in quantitative-trait genome-wide association studies (GWAS). A …

Genome-wide association studies are performed to correlate a number of diseases and
other physical or even psychological conditions (phenotype) with substitutions of …

The surge in availability of genomic data holds promise for enabling determination of
genetic causes of observed individual traits, with applications to problems such as discovery …

The substitution of nucleotides at specific positions in the genome of a population, known as
single-nucleotide polymorphisms (SNPs), has been correlated with a number of important …

In bioinformatics, alignment is an essential technique for finding similarities between
biological sequences. Usually, the alignment is performed with the Smith-Waterman (SW) …

The investigation of highly-efficient parallel algorithms targeting modern heterogeneous
systems can provide bioinformaticians new mechanisms to find relations between genetics …

Epistasis detection is a fundamental application in the areas of bioinformatics and
biomedicine, providing important insights regarding the relationship between the human …

Abstract A Single Nucleotide Polymorphism (SNP) is a DNA variation occurring when a
single nucleotide differs between individuals of a species. Some conditions can be …