Nucleic acid degradation as barrier to gene delivery: a guide to understand and overcome nuclease activity

H Zhang, J Vandesompele, K Braeckmans… - Chemical Society …, 2024 - pubs.rsc.org
Gene therapy is on its way to revolutionize the treatment of both inherited and acquired
diseases, by transferring nucleic acids to correct a disease-causing gene in the target cells …

Integrating artificial intelligence and nanotechnology for precision cancer medicine

O Adir, M Poley, G Chen, S Froim, N Krinsky… - Advanced …, 2020 - Wiley Online Library
Artificial intelligence (AI) and nanotechnology are two fields that are instrumental in realizing
the goal of precision medicine—tailoring the best treatment for each cancer patient. Recent …

Engineered metallacycle‐based supramolecular Photosensitizers for effective Photodynamic Therapy

L Tu, C Li, X ** applications
N Hildebrandt, CM Spillmann, WR Algar, T Pons… - Chemical …, 2017 - ACS Publications
Luminescent semiconductor quantum dots (QDs) are one of the more popular nanomaterials
currently utilized within biological applications. However, what is not widely appreciated is …

Simultaneous Detection of L‐Lactate and D‐Glucose Using DNA Aptamers in Human Blood Serum

PJJ Huang, J Liu - Angewandte Chemie International Edition, 2023 - Wiley Online Library
L‐lactate is a key metabolite indicative of physiological states, glycolysis pathways, and
various diseases such as sepsis, heart attack, lactate acidosis, and cancer. Detection of …

Gold nanoparticles for in vitro diagnostics

W Zhou, X Gao, D Liu, X Chen - Chemical reviews, 2015 - ACS Publications
IVD test is a crucial component of clinical care that performs a diagnostic test on biological
samples that have been taken from a living body, such as blood, urine, and tissue.(1) Such …

Quantum dots for Förster resonance energy transfer (FRET)

MC Dos Santos, WR Algar, IL Medintz… - TrAC Trends in Analytical …, 2020 - Elsevier
The analysis of biomolecular interactions using quantum dots (QDs) as both FRET donors
and acceptors has become an established technique in the life sciences. This development …