Endocrine disorders in Prader-Willi syndrome: a model to understand and treat hypothalamic dysfunction
M Tauber, C Hoybye - The Lancet Diabetes & Endocrinology, 2021 - thelancet.com
Prader-Willi syndrome is a rare genetic neurodevelopmental disorder resulting from the loss
of expression of maternally imprinted genes located in the paternal chromosomal region …
of expression of maternally imprinted genes located in the paternal chromosomal region …
Ghrelin's relationship to blood glucose
Much effort has been directed at studying the orexigenic actions of administered ghrelin and
the potential effects of the endogenous ghrelin system on food intake, food reward, body …
the potential effects of the endogenous ghrelin system on food intake, food reward, body …
Ghrelin deletion and conditional ghrelin cell ablation increase pancreatic islet size in mice
Ghrelin exerts key effects on islet hormone secretion to regulate blood glucose levels. Here,
we sought to determine whether ghrelin's effects on islets extend to the alteration of islet size …
we sought to determine whether ghrelin's effects on islets extend to the alteration of islet size …
[HTML][HTML] A LEAP 2 conclusions? Targeting the ghrelin system to treat obesity and diabetes
Background The hormone ghrelin stimulates food intake, promotes adiposity, increases
body weight, and elevates blood glucose. Consequently, alterations in plasma ghrelin levels …
body weight, and elevates blood glucose. Consequently, alterations in plasma ghrelin levels …
[HTML][HTML] The emerging role of snoRNAs in human disease
X Zhang, C Wang, S **a, F **ao, J Peng, Y Gao, F Yu… - Genes & …, 2023 - Elsevier
Small nucleolar RNAs (snoRNAs) play critical roles in various biological processes. The
aberrant expression or depletion of snoRNAs is related to various diseases. In previous …
aberrant expression or depletion of snoRNAs is related to various diseases. In previous …
Prader‐Willi syndrome: a model for understanding the ghrelin system
M Tauber, M Coupaye, G Diene… - Journal of …, 2019 - Wiley Online Library
Subsequent to the discovery of ghrelin as the endogenous ligand of growth hormone
secretagogue receptor 1a, this unique gut peptide has been found to exert numerous …
secretagogue receptor 1a, this unique gut peptide has been found to exert numerous …
Hypothalamic neuropeptides and neurocircuitries in Prader Willi syndrome
F Correa‐da‐Silva, E Fliers… - Journal of …, 2021 - Wiley Online Library
Abstract Prader‐Willi Syndrome (PWS) is a rare and incurable congenital
neurodevelopmental disorder, resulting from the absence of expression of a group of genes …
neurodevelopmental disorder, resulting from the absence of expression of a group of genes …
[HTML][HTML] Disrupting the ghrelin-growth hormone axis limits ghrelin's orexigenic but not glucoregulatory actions
Objective Acyl-ghrelin regulates eating, body weight, blood glucose, and GH secretion upon
binding to its receptor GHSR (growth hormone secretagogue receptor; ghrelin receptor) …
binding to its receptor GHSR (growth hormone secretagogue receptor; ghrelin receptor) …
Advances in the development of nonpeptide small molecules targeting ghrelin receptor
G Giorgioni, F Del Bello, W Quaglia… - Journal of Medicinal …, 2022 - ACS Publications
Ghrelin is an octanoylated peptide acting by the activation of the growth hormone
secretagogue receptor, namely, GHS-R1a. The involvement of ghrelin in several …
secretagogue receptor, namely, GHS-R1a. The involvement of ghrelin in several …
The LEAP2 response to cancer-related anorexia-cachexia syndrome in male mice and patients
The hormone ghrelin serves a protective role in cancer-related anorexia-cachexia syndrome
(CACS)—a condition in which plasma levels of ghrelin rise, its administration lessens CACS …
(CACS)—a condition in which plasma levels of ghrelin rise, its administration lessens CACS …