Organoid: Bridging the gap between basic research and clinical practice

G Weng, J Tao, Y Liu, J Qiu, D Su, R Wang, W Luo… - Cancer Letters, 2023 - Elsevier
Nowadays, the diagnosis and treatment system of malignant tumors has increasingly tended
to be more precise and personalized. And the existing tumor models are still unable to fully …

The role of erα and erβ in castration-resistant prostate cancer and current therapeutic approaches

NES Jefferi, AA Shamhari, NKZ Noor Azhar, JGY Shin… - Biomedicines, 2023 - mdpi.com
Castration-resistant prostate cancer, or CRPC, is an aggressive stage of prostate cancer
(PCa) in which PCa cells invade nearby or other parts of the body. When a patient with PCa …

Design, synthesis and biological evaluation of a new series of arylidene indanones as small molecules for targeted therapy of non-small cell lung carcinoma and …

MD Altıntop, A Özdemir, HE Temel… - European Journal of …, 2022 - Elsevier
In an attempt to identify small molecules for targeted therapy of non-small cell lung
carcinoma (NSCLC) and prostate cancer (PCa), new arylidene indanones (1–10) were …

Luteolin induces ferroptosis in prostate cancer cells by promoting TFEB nuclear translocation and increasing ferritinophagy

W Fu, L Xu, Y Chen, Z Zhang, S Chen, Q Li… - The Prostate, 2024 - Wiley Online Library
Background As the second most common cancer in men and the leading cause of cancer‐
related death, prostate cancer (PCa) could potentially be treated by inducing ferroptosis. In …

[HTML][HTML] Vitamin E in the management of pancreatic cancer: a sco** review

SO Ekeuku, EP Etim, KL Pang, KY Chin… - World Journal of …, 2023 - ncbi.nlm.nih.gov
Pancreatic cancer is the leading cause of cancer mortality worldwide. Research
investigating effective management strategies for pancreatic cancer is ongoing. Vitamin E …

Polyethylene glycol-phospholipid functionalized single-walled carbon nanotubes for enhanced siRNA systemic delivery

YF Tan, LW Hii, WM Lim, SK Cheong, CO Leong… - Scientific Reports, 2024 - nature.com
Small interfering RNAs (siRNA) technology has emerged as a promising therapeutic tool for
human health conditions like cancer due to its ability to regulate gene silencing. Despite …

Toward morphologically relevant extracellular matrix: nanofiber-hydrogel composites for tumor cell culture

X Liu, Y Ren, S Fu, X Chen, M Hu, F Wang… - Journal of Materials …, 2024 - pubs.rsc.org
The natural extracellular matrix (ECM) consists of a continuous integrated fibrin network and
a negatively charged proteoglycan-based matrix. In this work, we report a novel three …

Diverse Landscape of Genetically Engineered Mouse Models: Genomic and Molecular Insights into Prostate Cancer

JB Kaushal, S Takkar, SK Batra, JA Siddiqui - Cancer Letters, 2024 - Elsevier
Prostate cancer (PCa) is a significant health concern for men worldwide and is particularly
prevalent in the United States. It is a complex disease presenting different molecular …

Novel preclinical model, biomarker, treatment and drug delivery to address immune evasion in cancer

CW Mai, Z Macek Jilkova, K Dua, BH Goh - Frontiers in Immunology, 2024 - frontiersin.org
Immune cells play a critical role in the defense mechanisms for human health. However,
they can also catalyze tumorigenesis, and cancer progression (1). Consequently, cancer …

Stemness regulation in prostate cancer: prostate cancer stem cells and targeted therapy

H Liang, B Zhou, P Li, X Zhang, S Zhang… - Annals of …, 2025 - Taylor & Francis
Background Increasing evidence indicates that cancer stem cells (CSCs) and cancer stem-
like cells form a special subpopulation of cells that are ubiquitous in tumors. These cells …